Serum carcinoembryonic antigen (CEA) levels are associated with the decrease/loss of p27 immunohistochemical expression in non-small cell lung cancer. Preliminary results

I.  Abdukader; Mª  Pombo; S. Rodriguez- Segade; Alvaro  Ruibal; F.  Gude; Michel  Herranz; P Aguiar

doi:10.31487/j.ACO.2018.01.002

Serum carcinoembryonic antigen (CEA) levels are associated with the decrease/loss of p27

Serum carcinoembryonic antigen (CEA) levels are associated with the decrease/loss of p27 immunohistochemical expression in non-small cell lung cancer

Author Info

I. Abdukader Mª Pombo S. Rodriguez- Segade Alvaro Ruibal F. Gude Michel Herranz P Aguiar

Corresponding Author

P Aguiar
Molecular Imaging Group and Medical Physics, Faculty of Medicine, Universidade de Santiago de Compostela. IDIS, Santiago de Compostela, Spain

A B S T R A C T

Objective: to study the possible relation between immunohistochemical expression of p27 and serum carcinoembryonic antigen (CEA) levels in patients with non-small cell lung cancer (NSCLC) Material and Methods: The study group included 35 patients with NSCLC (15 squamous and 20 adenocarcinomas). Immunohistochemical expression of p27 was studied through the technique of tissuematrix using Tissue Arrayer Device, with monoclonal antibody M-T247 (Dako. Denmark). CEA serum levels were assayed using the “ECLIA” from Roche (Swiss). Results: P27 expression was noted in 27 cases (77,1%), being slightly (+) in 14 cases and strong (++) in 13 cases. CEA serum levels were higher (p:0,026) in + positive carcinomas (range: 2,2-570,7; median 7,6 ng/ml) than in ++ positive carcinoma (range: 1,5-35,1; median 2,7), but there were not differences between + positive and negative carcinomas. Likewise, there were statistically significant differences (p:0,043) between ++ positive group and -/+ group (r:0,8-766,7; median 6,3 ng/ml). Conclusions: Our results, preliminary do to the reduced number of patients included in the study, suggest that in patients with NSCLC, serum carcinoembryonic antigen levels can be associated with the decrease/loss of p27 immunohistochemical expression, important biological feature observed in various tumors, included lung carcinomas.

Article Info

Article Type

Research Article

Publication history

Received: Tue 18, Sep 2018
Accepted: Tue 02, Oct 2018
Published: Tue 16, Oct 2018

Copyright

© 2023 P Aguiar. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Hosting by Science Repository.
DOI: 10.31487/j.ACO.2018.01.002