Ten Year Retrospective Review of Bartter Syndrome at Sheikh Hospital 2008-2018

Author Info

Yalda Ravanshad Mohadese Golsorkhi Anoush Azarfar Sahar Ravanshad Zeinab seyedin Sepideh Bagheri Sepideh Seyedkaboli

Corresponding Author

Anoush Azarfar
Kidney Transplantation Complications Research Center, Mashhad University of Medical Sciences, Mashhad, Iran

A B S T R A C T

Objective: Bartter syndrome is a type of autosomal-recessive genetic abnormality with a low prevalence. In this abnormality, due to the mutations in the cotransporters and channeling proteins that are responsible for the transfer of sodium, chloride and potassium electrolytes in the thick ascending loop of Henle, the body throws out a large amount of these electrolytes through the urine. Early birth (prematurity), polyhydramnios, alkalosis and hypokalemia are the most important side effects of Bartter syndrome. Accordingly, quick detection of this can improve the treatment. Methods and Materials: The purpose of the current study is to investigate the symptoms of patients referred to Sheikh Hospital (Mashhad, Iran) over the past ten years due to Bartter's syndrome. Accordingly, by referring to patients' files, information about them is extracted from the historical documents and, statistically analyzed. Patients are also requested to complete a questionnaire, if necessary, through a telephone conversation. Results: Our findings indicated that symptoms including fever, polyuria, polydipsia, nausea and seizure, fever, physical and mental retardation, and one death among 14 participants were reported. Also, the biochemical findings of this study showed that potassium ion (k+ ) concentration in the serum of neonates was significantly lower than normal (p = 0.0001), and the concentration of calcium ions (Ca2+) and urea composition was significantly higher than normal (p = 0.0001). Also, sonographic findings showed that nephrocalcinosis and microlithiasis were observed in the participants in this study. Potassium chloride, normal saline, Brufen and Aldactone were used for treatment. Conclusion: It can be concluded that high concentrations of calcium and urea, low concentration of potassium ion, and complications such as fever and seizure along with polyhydramnios and nephrocalcinosis are the most important symptoms seen in patients with Bartter syndrome in the last 10 years.

Article Info

Article Type

Research Article

Publication history

Received: Mon 11, May 2020
Accepted: Sat 06, Jun 2020
Published: Mon 15, Jun 2020

Copyright

© 2023 Anoush Azarfar. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Hosting by Science Repository.
DOI: 10.31487/j.CEI.2020.02.03