Proceeding of Glioblastoma Multiforme (GBM): An Advanced Overview

Author Info

Niraj Kumar Srivastava Somnath Mukherjee

Corresponding Author

Niraj Kumar Srivastava
Department of Neurology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, India

A B S T R A C T

Glioblastoma multiforme (GBM) is a central nervous system tumor of grade IV histological malignancy according to the WHO classification. GBM is an extraordinary tumor and the worldwide incidence is less than 10 per 100,000 individuals. The prognosis of this tumor is meagre and survival rate is 15 months subsequent to diagnosis. Such an atrocious image of this tumor is responsible for a major issue of public health. This tumor develops from normal glial cells through multistep oncogenesis. Genetic alterations and deregulations of molecular pathways are responsible for development of both primary and secondary GBM. Diagnosis of GBM is performed by imaging techniques. These non-invasive imaging techniques are magnetic resonance imaging (MRI), computed tomography (CT) and Positron emission tomography (PET). Definitive diagnosis of GBM is based on histopathological examination of the intra operatively removed tumor or its parts, using traditional histological, cytologic and histochemical methods. NMR (Nuclear Magnetic Resonance) spectroscopy based possible diagnostic significance of GBM is also reported. Treatment of glioblastoma multiforme includes tumor resection, as well as radiotherapy and chemotherapy. Nanomedicine and bacterial protein based therapeutic approaches are in the developmental stage. There is always need of the development of new therapeutic approaches for GBM to improve the survival and quality of life.

Article Info

Article Type

Research Article

Publication history

Received: Sat 15, Aug 2020
Accepted: Mon 31, Aug 2020
Published: Mon 28, Sep 2020

Copyright

© 2023 Niraj Kumar Srivastava. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Hosting by Science Repository.
DOI: 10.31487/j.COCB.2020.02.02