A Child with Primary Leptomeningeal Melanoma

Author Info

Álvaro Pimenta Dutra Angelo Raphael Tolentino de Rezende Eric Grossi Morato Luiz Fernando Fonseca Marcos Grijo Pitangui Renato Pacheco de Melo

Corresponding Author

Álvaro Pimenta Dutra
General Pediatric Service of the João Paulo II Children’s Hospital/FHEMIG, (Hospital Infantil João Paulo II/Fundação Hospitalar de Minas Gerais), Brazil

A B S T R A C T

Primary malignant melanoma of the meninges is an exceedingly rare neoplasm. Usually its symptoms include raised intracraneal pressure resulting from hydrocephalus seconday to tumoral obliteration of cisternal basal cisterns, but the passage of time from initial symptomalogy to diagnosis is frequently delayed. A 12-year-old male with primary letomeningeal melanoma is reported. At the beginning, he presented with vomiting, headache, complex seizures, fever four months before the admission in the hospital where progressive loss of consciouness after admission. Lumbar puncture reveled high protein level, normal glucose level and 50 leucocytes/mm3 with 86% polymorphic cells. Magnetic ressonance imaging of the brain was referred and in T1-weighted images revealed a diffuse enhancement of the leptomeninges on right frontal cortical. An open brain biopsy trough was performed, after exclusion of the infectious nervous system disease. Histological examination revealed massive infiltration of meninges with brown tumor cells. These cells stained positive for HMB-45, S-100 protein and vimentin. The patient received post operative radiation therapy, but died after three months of the diagnosis with septic shock and epileptical status

Article Info

Article Type

Case Report

Publication history

Received: Sun 14, Jun 2020
Accepted: Mon 29, Jun 2020
Published: Fri 03, Jul 2020

Copyright

© 2023 Álvaro Pimenta Dutra. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Hosting by Science Repository.
DOI: 10.31487/j.COR.2020.07.06