Cryptococcal Endocarditis in a Woman with Metastatic Non-Small Cell Lung Cancer: A Case Report and Review of the Literature

Author Info

Tony Kurian Jason Peng Courtney Regan Wagner Fritzie S. Albarillo

Corresponding Author

Tony Kurian
Moffitt Cancer Center/USF, Tampa, Florida, USA

A B S T R A C T

Epidermal growth factor receptor tyrosine kinase inhibitors (EGFR-TKIs) have demonstrated improved progression-free survival benefits and decreased treatment-related side effects, and therefore are now considered first-line of treatment of EGFR mutated, metastatic non-small cell lung carcinoma (NSCLC). Cryptococcal endocarditis is an extremely rare clinical entity with only seven reported cases in the literature. Prior cases were seen in patients with a history of rheumatic heart disease or prior valve replacement surgery. Little is known regarding the natural history and optimal management of Cryptococcal endocarditis, given the limited available data. We present a case of Cryptococcal endocarditis and meningitis in a patient with metastatic NSCLC receiving targeted therapy with an EGFR-TKI with no history of significant cardiac disease.

Article Info

Article Type

Case Report and Review of the Literature

Publication history

Received: Wed 08, Jul 2020
Accepted: Tue 21, Jul 2020
Published: Mon 27, Jul 2020

Copyright

© 2023 Tony Kurian. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Hosting by Science Repository.
DOI: 10.31487/j.JCMCR.2020.02.06