The Effect of Uric Acid and Bilirubin Levels on Type 2 Diabetes Mellitus Development in Prediabetic Patients

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Alper Alay Aslı Kısacık Burak Furkan Demir Dilek Berker Duygu Güzel İhsan Ateş Nisbet Yılmaz

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Burak Furkan Demir
Sağlık Bilimleri University, Ankara Numune Health Application and Research Center, Departmen of Internal Medicine, Ankara, Turkey

A B S T R A C T

Background: This study aims to investigate whether or not uric acid and bilirubin have a role in the development of type 2 diabetes mellitus (T2DM) in prediabetic patients. Methods: 93 patients were included in the study. These patients were diagnosed as being prediabetic using the oral glucose tolerance test, and they also had their serum uric acid and total bilirubin measured during the follow-up application (1 - 5 years). Results: 17 out of the 93 patients developed T2DM during the study period. The only significant difference between the T2DM group and the non-T2DM group was OGTT 0.min and 120.min (p=0.001 and p=0.007, respectively). Analysis of the relationship between age, sex, HbA1c, uric acid, total bilirubin, direct bilirubin levels and T2DM development showed that none of the aforementioned risk factors were related with diabetes development. In the non-T2DM group, the median total bilirubin level was only found to be higher in the baseline assessment (p=0.042). Conclusion: It was found that uric acid and bilirubin had no effect on the development of diabetes in the 1-5-year follow-up of prediabetic patients. Randomized-controlled studies of a larger number of patients and sufficient follow-up time are required to provide clearer data on this topic.

Article Info

Article Type

Original Article

Publication history

Received: Sun 15, Sep 2019
Accepted: Mon 02, Dec 2019
Published: Wed 18, Dec 2019

Copyright

© 2023 Burak Furkan Demir. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Hosting by Science Repository.
DOI: 10.31487/j.JDMC.2019.02.02