Deficient Activity of FAD-Linked Glycerophosphate Dehydrogenase in the Mitochondria of Insulin-Producing Pancreatic Islets B-Cells: A Possible Cause of the Metabolic Syndrome

Author Info

Willy J. Malaisse Zoheir Mellouk

Corresponding Author

Willy J. Malaisse
Department of Biochemistry, Université Libre de Bruxelles, Brussels, Belgium

A B S T R A C T

A deficient activity of mitochondrial FAD-linked glycerophosphate dehydrogenase in insulin-producing pancreatic islet B-cells was recently identified in selected animal models of non-insulin-dependent diabetes mellitus. The incidence of this enzymatic defect remains however to be unambiguously documented in type-2 diabetic patients. The present review mainly aims at speculating that the altered recognition of nutrients, especially D-glucose, by pancreatic B-cells, as resulting from the abovementioned enzymatic perturbation could also eventually lead to the development of the metabolic syndrome (MetS).

Article Info

Article Type

Research Article

Publication history

Received: Tue 03, Dec 2019
Accepted: Mon 16, Dec 2019
Published: Wed 15, Jan 2020

Copyright

© 2023 Willy J. Malaisse. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Hosting by Science Repository.
DOI: 10.31487/j.JDMC.2019.02.03