An increase in corrected QT interval may indicate a good clinical response to amitriptyline in female patients with burning mouth syndrome

Author Info

Lou Mikuzuki Yuma Aota Akira Toyofuku Miho Takenoshita Takahiko Nagamine Takayuki Suga Takeshi Watanabe Trang T.H Tu

Corresponding Author

Takahiko Nagamine
Department of Psychiatric Internal Medicine, Sunlight Brain Research Center, Yamaguchi, Japan

A B S T R A C T

Burning mouth syndrome (BMS) is characterized by a burning sensation of the oral mucosa in the absence of underlying causes. BMS patients can pose a therapeutic challenge to clinicians. Amitriptyline has been a first-line treatment for BMS and is known to prolong corrected QT interval (QTc) in a dose dependent manner. However, little is known about the QTc lengthening effect of amitriptyline at analgesic dosages. The objective of this study was to evaluate changes in QTc in female BMS patients treated with amitriptyline. We conducted a single-center retrospective observational study and evaluated 40 female BMS patients. The QTc interval did not show statistically significant increase with amitriptyline (p=0.1502). However, the change in QTc of amitriptyline-responders was significantly longer than that of nonresponders (p=0.0142). The change in QTc may be a non-invasive maker of clinical responses to amitriptyline in female BMS patients.

Article Info

Article Type

Research Article

Publication history

Received: Sun 01, Jul 2018
Accepted: Fri 13, Jul 2018
Published: Sun 22, Jul 2018

Copyright

© 2023 Takahiko Nagamine. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Hosting by Science Repository.
DOI: 10.31487/j.NNB.2018.10.005