A Review of Pre-Clinical Studies for the Treatment of Neonatal Brain Injury

Author Info

Bryan Kolb Preston Williams

Corresponding Author

Bryan Kolb
Department of Neuroscience, University of Lethbridge, Lethbridge, Alberta, Canada

A B S T R A C T

The developing brain is especially sensitive to perturbations such as hypoxia-ischemia (HI) or surgical ablation in the perinatal period. We first review and contrast the effects perinatal HI and surgical perturbation in laboratory rats. The developing brain is also very responsive to a wide range of other experiences that can induce remarkable neural plasticity in both the normal and perinatally injured brain. We next review the factors that influence this plasticity in both the normal and perinatal injured. We consider treatments that stimulate cerebral and behavioural plasticity, especially in the motor systems. The goal is to draw attention to possible treatments that could be translated from perinatal surgical ablation to the HI model and eventually to the clinic.

Article Info

Article Type

Review Article

Publication history

Received: Mon 16, Mar 2020
Accepted: Tue 31, Mar 2020
Published: Tue 07, Apr 2020

Copyright

© 2023 Bryan Kolb. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Hosting by Science Repository.
DOI: 10.31487/j.NNB.2020.01.07