In silico Analysis of Alkaloids for Therapeutic Use in Treatment of Alzheimer's Disease by Targeting Acetylcholinesterase Enzyme

Author Info

Muhammad Sibte Hasan Mahmood Tiyyaba Furqan Muaaz Karim Sidra Batool

Corresponding Author

Sidra Batool
Department of Biosciences, COMSATS University, Chak Shahzad, Islamabad, Pakistan

A B S T R A C T

Alzheimer’s is a progressive mental deterioration associated with the degeneration of the cognition activities and memory loss. It is considered to be a multifactorial disease. One of the causes of the Alzheimer’s disease is the low concentration of the neurotransmitter named acetylcholine (ACh) at the synaptic cleft. Thus, inhibitor of Acetylcholinesterase (AChE), an enzyme whose function is to degrade the acetylcholine, is proved to be a promising candidate to treat this disease. Among the inhibitors are the natural alkaloids that also have an inhibitory effect on the AChE. In this study we have focused on the simple derivates of beta carbolime (a group of alkaloids) and studied their interaction with AChE via rigid protein-ligand docking approach.

Article Info

Article Type

Research Article

Publication history

Received: Tue 04, May 2021
Accepted: Fri 14, May 2021
Published: Fri 28, May 2021

Copyright

© 2023 Sidra Batool. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Hosting by Science Repository.
DOI: 10.31487/j.NNB.2021.02.02