Mechanical properties of 3D bioprinted dermis: characterization and improvement

Author Info

Amélie Thépot Christophe A. Marquette Edwin J. Courtial Marion Albouy Mélissa Dussoyer Morgan Dos Santos

Corresponding Author

Christophe A. Marquette
13d.FAB, Univ Lyon, Université Lyon1, CNRS, INSA, CPE-Lyon, ICBMS, UMR 5246, 43, Bd du 11 novembre 1918, 69622 Villeurbanne cedex, France

A B S T R A C T

Bioprinting is a promising way to create native-equivalent tissues for skin replacement in several pathologies and trauma. These last few years, various constructs have been reported, composed of fibroblasts and keratinocytes used to recapitulate the dermo-epidermal structure. However, the ability to control and characterize the mechanical properties of such constructs is a critical point to insure the transfer of these engineered products to clinic in a near future. In the present study, we had investigated the modulation of the biomechanics of a bioprinted dermis model through physical constrain during tissue maturation. Two passive tension devices were then designed and tested to mature the tissue after printing. Decrease in tissue retraction and increase of collagen I densities, associated to modulations of Young’s modulus were obtained after 20 days of tissue maturation. Taken together, these results attest for the first time in literature of promising methods to modulate the mechanical properties of bioprinted skin models.

Article Info

Article Type

Research Article

Publication history

Received: Wed 02, Jan 2019
Accepted: Wed 16, Jan 2019
Published: Wed 30, Jan 2019

Copyright

© 2023 Christophe A. Marquette. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Hosting by Science Repository.
DOI: 10.31487/j.RGM.2019.01.001