Risk Factors of Survival in Dedifferentiated Liposarcoma

Author Info

Kevin Nguyen Jonathan Gootee Sarah Aurit Sara Albagoush Christina Curtin Peter Silberstein

Corresponding Author

Kevin Nguyen
Creighton University School of Medicine, Omaha, Nebraska, USA

A B S T R A C T

Background: Liposarcoma is the most common malignant soft tissue sarcoma for which surgical resection is the most utilized therapeutic option. In this study, we aimed to explore the associations of surgical margins among other risk factors on survival in patients with dedifferentiated liposarcoma. Patients and Methods: The National Cancer Database (NCDB) was used to select patients with dedifferentiated liposarcoma to determine if surgical margins were associated with worse overall survival after controlling for age, gender, race, Charlson-Deyo score, anatomic site, treatment approach, tumor size, tumor grade, and presence of metastases through multivariable analysis. Results: Multivariable analyses showed that mortality risk increased for dedifferentiated liposarcoma patients with the following: older age, male, metastasis, high tumor grade, macroscopic residual tumor compared to no residual tumor. Conclusion: Older age, male sex, presence of metastasis, retroperitoneal/abdomen primary site, high grade tumors, and macroscopic residual tumor present after surgery led to an increased risk of mortality.

Article Info

Article Type

Research Article

Publication history

Received: Thu 07, Jan 2021
Accepted: Sat 23, Jan 2021
Published: Tue 02, Feb 2021

Copyright

© 2023 Kevin Nguyen. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Hosting by Science Repository.
DOI: 10.31487/j.SCR.2021.02.02