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- About Journal American Journal of Medicinal Chemistry (ISSN 2733-2519)
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American Journal of Medicinal Chemistry (Am J Med Chem) (ISSN 2733-2519)
Aims and Scope
American Journal of Medicinal Chemistry publishes articles which contribute to an understanding of the relationship between molecular structure and biological activity or mode of action. Papers covering design synthesis, and biological evaluation of novel biologically active compounds, diagnostic agents, or labeled ligands employed as pharmacological tools are welcome.
The journal also accepts articles on structural biological studies (X-ray, NMR, etc.) of relevant ligands and targets with the aim of investigating molecular recognition processes in the action of biologically active compounds. Novel methodology with broad application to medicinal chemistry are accepted but only if the methods have been tested on relevant molecules. American Journal of Medicinal Chemistry focusses in presenting original research findings for generating relevant case stories and critical reviews and for stimulating commentaries and professional debates in Letters to the Editor.
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Manuscripts number will be provided to the corresponding author within 72 hours for the respective manuscript submitted.
- 14 day review process with international peer-review standards
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In Press Volume 4, Issue 1
Editor-in-chief
JUN XU
Professor, Director and Founder of Research Center for Drug Discovery, Sun Yat-Sen University
Adjunct Professor of University of Pittsburgh (USA) and RMIT University (Australia)
Fellow of Royal Society of Chemistry
Guangzhou, China
Biography
I became Professor of Medicinal Chemistry and CADD, and the Director and Founding Professor of the Research Center for Drug Discovery (RCDD) and the HPC Center for Life Sciences (HPCCLS) at Sun Yat-Sen University (SYSU) in Guangzhou, China in 2009. Prior to joining SYSU, I worked in the pharmaceutical industry, practicing chemoinformatics and computer-aided drug design (CADD) for over 25 years. I was a director & Fellow of CADD at DPI/Biofocus, a principal scientist managing the computational chemistry and chemoinformatics group at Boehringer Ingelheim Pharmaceuticals, Inc. (BIPI). Before joining BIPI, I held an R&D director position at BIO-RAD Sadtler Division and was a senior staff scientist developing drug discovery related technology at both OMG (now merged with Accelrys) and Tripos. RCDD consists of the laboratories of drug design methodology, structure biology, phytochemistry, medicinal chemistry, biological assay, and compound repository. My research involves chemistry, pharmacy and informatics. Since the last century, I have been developing algorithms for chemoinformatics / bioinformatics and pharmaceutical innovations, such as GMA (chemical database search engine, 1980s) CPA (fuzzy graph algorithm for protein structure determination from multi-dimensional NMR, 1990s), SCA (clustering large compound libraries, 2000s) and DLI algorithm (drug-like index, 2000s); WEGA (3D molecular superimposing, 2010s) DSGA (de novo frequent substructures recognition, 2010s). With these methods, my team discovered drug leads against osteoporosis, aging, glioblastoma, nasopharyngeal carcinoma, and other metabolic diseases. The leads against osteoporosis and glioblastoma have entered in the later pre-clinic studies and transferred to industry. I have published more than a hundred papers in international peer-reviewed journals. I am the inventor of more than 20 patents.
Editorial board
- Yaniv Lavon
- Jun Xu
- Ayman Helmy Kamel Mohamed
- GIUSEPPE LANZA
- Charles Larson
- Emmanuel Olu Megbelayin
- Zhongren (David) Zhou
- Ramona Moles
- Azizollah Nezhadali
- HEMANGA HAZARIKA
- Prof. Lallan Mishra
- Nahla Ahmed Hassan Farag
- A. V. Raghu
Yaniv Lavon
Professional Manager and Researcher
Department of Animals Science
The Hebrew University of Jerusalem
Israel
About Me
Teaching assistant in the Faculty of Agriculture, Department of Animal Science (2003-2011) in the following courses: Biology of Lactation Comparative Reproductive Biology Dairy Cattle Management Bioclimatology of Domestic Animals Ruminants diseases AWARDS AND GRANTS Recipient of a scholarship from the Israel Cattle Breeders’ Association in 2006. Recipient of a scholarship from the Israel Cattle Breeders’ Association in 2008. Recipient of the "Laper" scholarship in 2007. Recipient of the "Whole Organism" scholarship in 2008, donated by the Ministry of Agriculture.
Jun Xu
Professor, Director and Founder of Research Center for Drug Discovery, Sun Yat-Sen University
Adjunct Professor of University of Pittsburgh (USA) and RMIT University (Australia)
Fellow of Royal Society of Chemistry
Guangzhou, China
About Me
I became Professor of Medicinal Chemistry and CADD, and the Director and Founding Professor of the Research Center for Drug Discovery (RCDD) and the HPC Center for Life Sciences (HPCCLS) at Sun Yat-Sen University (SYSU) in Guangzhou, China in 2009. Prior to joining SYSU, I worked in the pharmaceutical industry, practicing chemoinformatics and computer-aided drug design (CADD) for over 25 years. I was a director & Fellow of CADD at DPI/Biofocus, a principal scientist managing the computational chemistry and chemoinformatics group at Boehringer Ingelheim Pharmaceuticals, Inc. (BIPI). Before joining BIPI, I held an R&D director position at BIO-RAD Sadtler Division and was a senior staff scientist developing drug discovery related technology at both OMG (now merged with Accelrys) and Tripos. RCDD consists of the laboratories of drug design methodology, structure biology, phytochemistry, medicinal chemistry, biological assay, and compound repository. My research involves chemistry, pharmacy and informatics. Since the last century, I have been developing algorithms for chemoinformatics / bioinformatics and pharmaceutical innovations, such as GMA (chemical database search engine, 1980s) CPA (fuzzy graph algorithm for protein structure determination from multi-dimensional NMR, 1990s), SCA (clustering large compound libraries, 2000s) and DLI algorithm (drug-like index, 2000s); WEGA (3D molecular superimposing, 2010s) DSGA (de novo frequent substructures recognition, 2010s). With these methods, my team discovered drug leads against osteoporosis, aging, glioblastoma, nasopharyngeal carcinoma, and other metabolic diseases. The leads against osteoporosis and glioblastoma have entered in the later pre-clinic studies and transferred to industry. I have published more than a hundred papers in international peer-reviewed journals. I am the inventor of more than 20 patents.
Ayman Helmy Kamel Mohamed
Professor
Analytical Chemistry, Chemistry Department
Ain Shams University, Cairo
Cairo, Egypt
About Me
Ayman is a member of the Technical Committee for the establishment of regulations and educational programs within the committees of the Ministry of Higher Education to supervise and follow-up national projects for the establishment of universities and educational institutions and research in the Arab Republic of Egypt. 1. Head of the Central Laboratory for microanalysis, Faculty of Science, Ain shams University from Nov.2015 till now. 2. Head of organizing committee for the first international scientific conference of Faculty of Science- Ain Shams University” New Frontiers in Science”, Hurgada, Red Sea, Egypt October 24-27, 2017. 3. Head of organizing committee for the second international scientific conference of Faculty of Science-Ain Shams University” New Frontiers in Science”, Hurgada, Red Sea, Egypt October 24 – 27, 2018. 4. Member of the Graduate Studies Committee-Chemistry Department, Faculty of Science, Ain Shams University. 5. Head of petroleum chemistry program, Faculty of arts and Science, American University of Nigeria, Yola, Nigeria. 6. Chemistry program coordinator, College of Science, Qassim University. 7. Member of Accreditation committee, College of Science, Qassim University. 8. Head of Assessment & Academic Accreditation committee, Chemistry Department, College of Science, Qassim University. 9. Head of laboratories, Equipments & Services committee, Chemistry Department, College of Science, Qassim University. Head of Higher education & research committee, Chemistry Department, College of Science, Qassim University.
GIUSEPPE LANZA
Senior University Researcher
Department of General Surgery and Medical-Surgical Specialties. Professor of Applied Medical Sciences Technologies
University of Catania, Catania (Italy)
CATANIA (ITALY) , Italy
About Me
Giuseppe Lanza has Participated at Several International, National & Local Conference :
- THE ANNUAL MEETING (MARCH 2015) OF THE WORLD ASSOCIATION OF SLEEP MEDICINE (WASM) IN SEOUL (SOUTH KOREA)
- THE 9TH INTERNATIONAL CONGRESS ON VASCULAR DEMENTIA (ICVD) (OCTOBER 2015) IN LJUBLJANA (SLOVENIA)
- THE INTERNATIONAL RLS STUDY GROUP (IRLSSG) AND EUROPEAN RLS STUDY GROUP (EU-RLSSG) RLS/WED SCIENCE SUMMIT (OCTOBER 2015) IN PACIFIC GROVE, CA – USA
Author of Some Famous Book :
- Bella R, Pennisi G, Cantone M, Palermo F, Pennisi M, Lanza G, Zappia M, Paolucci S. Clinical presentation and outcome of geriatric depression in subcortical ischemic vascular disease.
- Pennisi G, Ferri R, Lanza G, Cantone M, Pennisi M, Puglisi V, Malaguarnera G, Bella R. Transcranial magnetic stimulation in Alzheimer’s disease: a neurophysiological marker of cortical hyperexcitability.
Charles Larson
Professor
Department of Communication Sciences and Disorders
Northwestern University
United States
Biography
My primary area of interest is in neural mechanisms of voice control. I have worked on this general topic for over 40 years. My early work was done on nonhuman primates in which we attempted to learn which areas of the brain are involved in vocalization through the brain lesioning approach. I also worked with Erich Luschei studying neural mechanisms of jaw control, and in this work, I learned how to do single unit recordings from the brain in awake behaving animals. In this work we made important discoveries of the role of jaw muscle spindle afferent endings on jaw control (J. Neurophysiology; J Physiology (London)). Thereafter with my move to Northwestern University, I used the single unit recording methods to study neural function in the midbrain periaqueductal gray and nucleus ambiguous in monkeys as they were vocalizing. This work demonstrated that the midbrain periaqueductal gray played an important role in the coordination of laryngeal and respiratory muscles on vocal control (Brain Research, Experimental Brain Research and the Journal of Neurophysiology). In about 1995 I developed a technique to study neural control of the voice by perturbing voice auditory feedback. This work was based on the well-established technique of perturbation analysis that has been used in other motor systems. In this work, we measure voice fundamental frequency and voice amplitude changes during steady vowel vocalizations as well as during speech following perturbations in auditory feedback. This technique has been widely accepted and is now used by voice scientists around the world. Our most recent work has involved ERP recording in the voice perturbation technique, and this research has led us to insightful discoveries of brain function during human vocalization. Namely, we have determined that voice pitch perturbations presented at the onset of vocalization activate a system that is important for identification of one’s own voice. Perturbations presented after the onset of vocalization trigger mechanisms that are involved in correcting for errors in vocal production. I began working with Don Robin about six years ago, and through this collaboration we have been using neuroimaging techniques (fMRI and PET) along with transcranial magnetic stimulation to study the role of auditory feedback in voice control. This work has also led to important papers on structural equation modeling and dynamic causal modeling of the neural circuitry involved in the role of auditory feedback in voice control (Neuroimage, Neuropsychologia). Most recently, working with my post-doctoral fellow, Dr. Sona Patel, we developed a new technique for the study of volitional mechanisms of voice control based on perturbations in voice auditory feedback. This technique allows us to investigate neural correlates of feedforward mechanisms of voice control. Altogether, the voice perturbation studies, ERP recordings, fMRI neuroimaging and neural modeling are leading to a better understanding of the neural mechanisms involved in the role of auditory feedback and voice control. My background in the establishment of new techniques for the study of neural mechanisms of voice control places me in an ideal position to participate in the studies in this proposal.
Emmanuel Olu Megbelayin
Senior Lecturer
Department of Ophthalmology
University of Uyo
Nigeria
Biography
He is a versatile Ophthalmologist with over 44 published scholarly articles and obtained Ophthalmology Fellowships from National Postgraduate Medical College of Nigeria, Sankara Eye Hospital Academy of Ophthalmology, Chennai, India, Chang Gung Memorial Hospital, Kaohsiung, Taiwan, and Aravind Eye Hospital, Pondicherry, India. Currently a Senior Lecturer and Consultant Ophthalmologist/Vitreo-retinal Surgeon to University of Uyo and University of Uyo Teaching Hospital respectively. A recipient of Commonwealth scholarship with several presentations in local and international Ophthalmology conferences.
Zhongren (David) Zhou
Associate Professor
University of Rochester Medical Center
United States
Biography
Dr. Zhongren (David) Zhou is currently working as Associate Professor in Division of Cytopathology and GI pathology University of Rochester Medical Center New York. He has done his Bachelor’s in medicine from North China University of Science and Technology, Tangshan, China. Dr. Zhongren (David) Zhou has received his PhD in Neurobiology, Shanghai Medical College, Fudan University, Shanghai, China. He has worked in various scientific societies like Western New York Society of Pathologists, United States & Canadian Academy of Pathology, Chinese American Pathologists Association, American Society of Cytopathology, American Society of Cytopathology, College of American Pathologists, American Society for Clinical Pathologists and Society of Neuroscience. Dr. Zhongren (David) Zhou has published around 50 scientific articles. Dr. Zhongren (David) Zhou is editorial board of 4 journals and has many reviewed publications. Dr. Zhongren (David) Zhou research interests include early diagnosis of esophageal adenocarcinoma and precancerous lesions by cytology and genome sequencing methods.
Ramona Moles
Research Assistant
University of Kansas Medical Center
United States
Biography
Dr. Ramona Moles is currently working as Graduate Research Assistant at Department of Pathology, University of Kansas Medical Center (USA). She received her Bachelors in Biological Sciences from University of Bologna (Italy). Dr. Ramona Moles received her Ph.D. Graduate Student Research Assistant in the Center for Viral Oncology and PhD student in the Department of Pathology and Laboratory Medicine, University of Kansas Medical Center. Dr. Ramona Moles currently on the editorial board of Journal of Oncology and Hematology, Journal of Pathology & Microbiology, Annals of Carcinogenesis, Austin Oncology, SM Journal of Hematology & Multiple Myeloma. Dr. Ramona Moles has many reviewed publications. Dr. Ramona Moles research interests include Molecular Toxicology, Pathway Deregulation in Human, DNA repair alteration in ATL leukemia.
Azizollah Nezhadali
Professor
Analytical Chemistry
Payame Noore University(PNU), Mashhad
Mashhad, Iran
HEMANGA HAZARIKA
Researcher
Division of Pharmaceutical Technology
Defence Research Laboratory (DRL) DRDO, Ministery of Defense
Tezpur, India
Prof. Lallan Mishra
Professor
Chemistry
Banaras Hindu University
Varanasi, India
Nahla Ahmed Hassan Farag
Professor
Pharmaceutical Medicinal Chemistry, Faculty of Pharmacy
Misr International University MIU Cairo
Cairo, Egypt
A. V. Raghu
Professor
Department of Chemistry
Jain Deemed-to-be University
India
Current Issue Volume 3, Issue 1
Submit Manuscript
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For submission authors can directly submit manuscript to articles@sciencerepository.org
Manuscripts number will be provided to the corresponding author within 72 hours for the respective manuscript submitted.
- 14 day review process with international peer-review standards
- Timeline of processing from Submission to Publication is 30 days
- Manuscript will be published within 7 days of acceptance
Archive
We are currently preparing the issue. Will be updated soon.