Table 2: The immunomodulatory proteins of platelet cell
surface proteins, which are either pro- or anti-inflammatory [22].
|
Pro-inflammatory |
Anti-inflammatory |
|
Selectin family: P-Selectin
recruits neutrophils |
Transforming growth
factor-beta: immunosuppressive mediator |
|
CD4 and CD154(CD40L) – interactions between lymphocytes and antigen
presenting cells (dendritic cells/macrophages) – upregulate pro-inflammatory mediators (VCAM) – CD154 release IL-6 and tissue factor and upregulate
E-selectin and P-selectin |
|
|
Toll-like receptors
recognize pathogens and release pro-inflammatory mediators (chemokines; IL-1;
TNF-alpha) |
|