Table 1: Optimization of reaction conditions for the synthesis of 1,3-diphenylpyrazole-chromenoquinolin-6-one compounds. Science Repository

Science Repository

Entry	Catalyst	Temperature (°C)	Time (h)	Solvent	Yield^a (%)
1	p-TSA	80	8	EtOH	20
2	p-TSA	100	8	H₂O	10
3	L-proline	100	8	EtOH	30
4	AcOH	80	8	EtOH	53
5	NH₂SO₃H	80	8	EtOH	65
6	NH₂SO₃H	100	8	EtOH	49
7	Amberlite IR-120 H	80	5	EtOH	86
8	Amberlite IR-120 H	100	5	H₂O	32
9	Amberlite IR-120 H	120	8	DMF	68
10	Amberlite IR-120 H	40	5	DCM	30
11	Amberlite IR-120 H	60	5	CHCl₃	55
12	Amberlite IR-120 H	80	5	ACN	60
13	Amberlite IR-120 H	85	8	EtOH-H₂O	51
14	Amberlite IR-120 H	rt	8	EtOH	30
15	--	rt	12	--	--
16	--	100	12	--	15
17	Amberlite IR-120 H	100	12	--	trace

^aIsolated yields