Table 1: Demographic, clinical, laboratory and echocardiographic parameters in the studied groups.
|
Variable |
PH-CHD patients |
CHD only patients |
Healthy control |
p |
p1 |
p2 |
p3 |
|
Age (months) |
8.3±2.6 |
8.7±3.1 |
8±2.5 |
NS |
|
|
|
|
Sex (male: female) |
26:24 |
23:27 |
25:25 |
NS |
|
|
|
|
Weight |
6.7±0.8 |
7.2 ±1.2 |
9.2±1.3 |
0.001 |
NS |
0.001* |
0.01* |
|
HR(b/m) |
124 ± 21.8 |
117.3 ±23.9 |
90.5 ± 18.9 |
0.001* |
NS |
0.001* |
0.001* |
|
RR (cycle/m) |
46.1 ± 7.5 |
43.6 ±6.9 |
35.2 ± 4.3 |
0.001* |
NS |
0.001* |
0.01* |
|
GDF-15 (nmol/ml) |
0.62 ± 0.2 |
0.21 ± 0.06 |
0.13 ± 0.02 |
<0.001* |
0.001* |
<0.001* |
<0.001* |
|
mPAP (mm Hg) |
47.3 ± 13.8 |
16.2 ± 4.5 |
12.6 ± 3.9 |
<0.001* |
<0.001* |
<0.001* |
NS |
|
PVR(Wood unit) |
3.1±0.9 |
1.5±0.3 |
|
|
|
|
|
|
RVOT FS% |
35.8 ± 8.2 |
33.5 ± 7.2 |
36.9 ± 4.9 |
NS |
|
|
|
|
RV E/A ratio |
1 ± 0.3 |
1.3 ± 0.2 |
1.3 ± 0.1 |
0.01* |
0.001* |
0.001* |
NS |
p: p value for comparison between the three studied groups.
p1: p value for comparison between PH-CHD and CHD groups.
p2: p value for comparison between PH-CHD and control groups.
p3: p value for comparison between CHD and control groups.
*means significant, NS: non-significant, HR: heart rate, b/m: beat per minute, RR: respiratory rate, GDF: growth differentiation factor, mPAP: mean pulmonary artery pressure, PVR: pulmonary vascular resistance, RVOT FS: right ventricular outlet fraction shortening, RV: right ventricle, E/A ratio: ratio of the early (E) to late (A) ventricular filling velocities.