Aminoglycoside

Gentamicin Number (%)

Amikacin Number (%)

Total Number (%)

Average dose (mg/kg/day)

5.2±1.9

17.7±4.8

N/A

Dose frequency

Conventional dosing

86 (65.2%)

48 (70.6%)

134 (67%)

Extended dosing

46 (34.8%)

20 (29.4%)

66 (33%)

Dosing based on ideal body weight

Correct dose

80 (60.6%)

52 (76.5%)

132 (66%)

Incorrect dose (total)

52 (40.2%)

16 (29.4%)

68 (34%)

Over-dosed

Conventional dosing

47(35.6%)

9 (13.2%)

56(28%)

Extended dosing        

5 (3.8%)

1 (1.4%)

6 (3%)

Under-dosed

Conventional dosing  

0 (0%)

3 (4.4%)

3 (1.5%)

Extended dosing

0 (0%)

3 (4.4%)

3 (1.5%)

Duration of therapy

2 to 5 days

29

5

34

6 to 9 days

46

16

62

10 to 13 days

49

35

84

≥14 days

8

12

20

Mean ± SD

8.28±3.48

9.75±2.78

8.78±3.33

Basis for prescription

Clinical judgment

46 (34.8%)

10 (14.7%)

56 (28%)

Microbiological sensitivity tests

86 (65.2%)

58 (85.3%)

144 (72%)

Monitoring parameters

Aminoglycoside blood level

2 (1.5%)

0 (0%)

2 (1%)

Renal function (SCr and BUN)

Before and after treatment

45 (34.1%)

30 (44.1%)

75 (37.5%)

Only before treatment

66 (50%)

31 (45.6%)

97 (48.5%)

Not done at all

21 (15.9%)

7 (10.3%)

28 (14%)

Incidence of nephrotoxicity

4 (8.8%)

3 (10%)

7 (9.3%)