Table 1: Modulators of radiation-induced fibrosis.
Modulator |
Biochemical signaling pathway |
Fibrotic manifestation |
TGFβ |
Smad dependent pathways |
a SMA collagen |
Cytokines |
Smad, NFκB |
EMT profibrotic responses |
TNFα |
NFκB |
profibrotic responses |
ROS/RNS |
DNA oxidation, secretion of MMPs |
ECM |