Table 3. Differences in SPME-GC-MS peaks and concentrations of biomarkers
between pairs of urine mixture samples for healthy volunteers, patients with
bladder cancer, and patients with prostate cancer (continued).
|
Peak # |
Compound |
parameters |
Healthy volunteers |
Bladder cancer |
Bladder cancer |
Prostate cancer
(endocrine therapy) |
Prostate cancer |
|||||
|
H1–3 |
H4–6 |
post-TUR K:Um |
pre-TUR K:Um |
post-TUR N:Um |
pre-TUR N:Um |
post-RP Pe:Um |
pre-RP Pe:Um |
post-RP P:Um |
pre-RP P:Um |
|||
|
70 |
unidentified |
peak height |
1.6×104 |
1.5×104 |
1.8×104 |
2.1×104 |
1.6×104 |
1.7×104 |
1.7×104 |
1.9×104 |
1.2×104 |
1.9×104 |
|
relat.to_healthy Um |
1.00 |
0.92 |
1.11 |
1.27 |
0.98 |
1.05 |
1.01 |
1.13 |
0.75 |
1.13 |
||
|
relat.to_#70 |
1.00 |
1.00 |
1.00 |
1.00 |
1.00 |
1.00 |
1.00 |
1.00 |
1.00 |
1.00 |
||
|
relat.to_#36 |
0.17 |
0.18 |
0.18 |
0.13 |
0.18 |
0.18 |
0.16 |
0.18 |
0.17 |
0.15 |
||
|
36 |
unidentified |
peak height |
9.7×104 |
8.5×104 |
9.9×104 |
1.6×105 |
9.0×104 |
9.7×104 |
1.1×105 |
1.0×105 |
7.2×104 |
1.2×105 |
|
relat.to_healthy Um |
1.00 |
0.88 |
1.02 |
1.65 |
0.93 |
1.00 |
1.10 |
1.07 |
0.74 |
1.25 |
||
|
relat.to_#70 |
5.90 |
5.59 |
5.44 |
7.65 |
5.65 |
5.64 |
6.42 |
5.57 |
5.87 |
6.50 |
||
|
relat.to_#36 |
1.00 |
1.00 |
1.00 |
1.00 |
1.00 |
1.00 |
1.00 |
1.00 |
1.00 |
1.00 |
||
|
87 |
unidentified |
peak height |
4,158 |
3,619 |
3,115 |
2,540 |
2,241 |
2,364 |
2,819 |
3,662 |
1,936 |
1,789 |
|
relat.to_healthy Um |
1.00 |
0.87 |
0.75 |
0.61 |
0.54 |
0.57 |
0.68 |
0.88 |
0.47 |
0.43 |
||
|
relat.to_#70 |
0.25 |
0.24 |
0.17 |
0.12 |
0.14 |
0.14 |
0.17 |
0.20 |
0.16 |
0.10 |
||
|
relat.to_#36 |
0.04 |
0.04 |
0.03 |
0.02 |
0.02 |
0.02 |
0.03 |
0.04 |
0.03 |
0.01 |
||
|
92 |
unidentified |
peak height |
1,771 |
1,387 |
2,157 |
1,495 |
1,722 |
1,147 |
2,195 |
1,720 |
1,612 |
2,099 |
|
relat.to_healthy Um |
1.00 |
0.78 |
1.22 |
0.84 |
0.97 |
0.65 |
1.24 |
0.97 |
0.91 |
1.19 |
||
|
relat.to_#70 |
0.11 |
0.09 |
0.12 |
0.07 |
0.11 |
0.07 |
0.13 |
0.09 |
0.13 |
0.11 |
||
|
relat.to_#36 |
0.018 |
0.016 |
0.022 |
0.009 |
0.019 |
0.012 |
0.021 |
0.017 |
0.022 |
0.017 |
||
post-antibiotic pro.: post-TUR K:Um with antibiotic prophylaxis;
TUR: Transurethral Resection; RP: Radical Prostatectomy.
All patient samples were mixtures of 25 urine
samples (5 patients × 5 samples). DB-5MS column is equivalent to CP Sil 8CB column.
Ratio of the peak height for the respective sample relative (relat.) to that of
an average of those for H1–3 and H4–6 mixture samples Um.
>10-fold (red) and 2–10-fold (blue) increases from the
peak height of the healthy volunteer in were highlighted.