Table 1: Clinical, demographic and laboratory data of study population stratified according to neurological function after acute ischemic stroke in Chinese patients with mechanical thrombectomy.
|
|
Neurological Improvement (NIHSS 0–4) |
Neurological Impairment (NIHSS 5–42) |
P |
|
Patients, n (%) |
88 |
151 |
|
|
Age (years), median (IQR) |
67(58-76) |
72(60-80) |
0.012*# |
|
Sex, n (%) |
|
|
0.912 |
|
Male, n (%) |
61(69.3) |
105(70.0） |
|
|
Female, n (%) |
27(30.7) |
45(30.0) |
|
|
Medical history, n (%) |
|
|
|
|
Hypertension |
60(68.2) |
105(70.0) |
0.769* |
|
Diabetes mellitus |
19(21.6) |
30(20.0) |
0.770* |
|
Hyperlipidemia |
3(3.4) |
16(10.7) |
0.081* |
|
Coronary artery disease |
17(19.3) |
42(28.0) |
0.134 |
|
Atrial fibrillation |
27(30.7) |
56(37.3) |
0.298 |
|
Transient ischemic attack |
0(0) |
3(2.0) |
0.299 |
|
Previous cerebral infarction |
14(15.9) |
27(18.0) |
0.680 |
|
Previous cerebral hemorrhage |
1(1.1) |
6(4.0) |
0.387 |
|
Smoking, n (%) |
|
|
0.245 |
|
Never smoker |
49(55.7) |
87(58.0) |
|
|
Former smoker |
13(14.8) |
12(8.0) |
|
|
Current smoker |
26(29.5) |
51(34.0) |
|
|
Baseline data |
|
|
|
|
NIHSS score on admission, median (IQR) |
11(8-16) |
17(13-22) |
<0.001*# |
|
Systolic BP, mmHg, median (IQR) |
138(123-158) |
143(128-159) |
0.390# |
|
Diastolic BP, mmHg, median (IQR) |
84(75-93) |
86(76-99) |
0.207# |
|
INR, median (IQR) |
0.99(0.93-1.09) |
1.02(0.93-1.12) |
0.329# |
|
Creatinine, umol/L, median (IQR) |
68.00(59.00-80.85) |
76.50(61.00-93.00) |
0.040*# |
|
FBG, mmol/L, median (IQR) |
5.87(5.01-6.99) |
6.61(5.60-8.23) |
<0.001*# |
|
TC, mmol/L, median (IQR) |
4.09(3.40-4.92) |
4.11(3.44-4.88) |
0.886# |
|
TG, mmol/L, median (IQR) |
1.06(0. 75-1.57) |
1.08(0.80-1.61) |
0.849# |
|
LDL, mmol/l, median (IQR) |
2.50(1.98-3.20) |
2.20(1.80-2.88) |
0.052*# |
|
HbA1c, %, median (IQR) |
5.80(5.55-6.45) |
5.90(5.50-6.50) |
0.883# |
|
UA, umol/l, median (IQR) |
278.50(226.00-372.50) |
314.40(236.00-396.00) |
0.071# |
|
HCY, umol/l, median (IQR) |
12.46(10.88-17.24) |
13.36(10.90-16.30) |
0.627# |
|
Anterior circulation, n(%) |
65(73.9) |
121(80.7) |
0.220 |
|
Posterior circulation, n(%) |
23(26.1) |
29(19.3) |
0.220 |
|
TOAST classification |
|
|
0.235 |
|
Large artery atherosclerosis, n (%) |
49(55.7) |
67(44.7) |
|
|
Cardioembolism, n (%) |
35(39.8) |
72(48.0) |
|
|
Others, n (%) |
4(4.5) |
11(7.3) |
|
|
IV thrombolysis, n (%) |
|
|
0.652 |
|
No thrombolysis |
49(55.7) |
79(52.7) |
|
|
Thrombolysis |
39(44.3) |
71(47.3) |
|
|
OTT, min, median (IQR) |
289(220-399) |
282(208-424) |
0.759*# |
Abbreviations: mRS, modified Rankin Scale; INR, International normalized ratios; FBG, Fasting blood glucose; TC, total cholesterol; TG, triglyceride; LDL, Low density lipoprotein; HbAc1, Glycated hemoglobin; UA, Uric Acid; HCY, homocysteine; TOAST, Trial of ORG 10172 in Acute Stroke Treatment Interval; OTT, from onset to treatment; *included into the multiple logistic regression models (P < 0.1). Additionally, traditional stroke risk factors such as Hypertension, Diabetes mellitus, Interval from onset to treatment were added into the model. # Calculated using Mann-Whitney U test.