Table 1: Cell culture models to study viruses (SARS‐CoV, H1N1, MERS‐CoV, SARS‐CoV‐2).

SARS-CoV-2

MERS-CoV

SARS-CoV

Influenza A (H1N1)

·        Vero cells [32]

·        Vero E6 cells [23, 24, 26, 27, 32]

·        Human airway epithelial cells [29]

·        human adenocarcinoma cells (A549), human liver cells (HUH7.0), and human embryonic kidney cells (HEK-293T) [25]

·        human lung epithelial (Calu-3) cells [15]

·        primary human alveolar epithelial cells and macrophages [28]

·        Caco2, CL14, HT-29, and DLD-1 [31]

·        Huh7 cells [10]

·        human airway epithelial cells [66, 68]

·        Monocyte-derived-dendritic cells (Mo-DCs) [20]

·        human adenocarcinoma cells (A549), ZN-R, ZLu-R, LGK-1-R, TT-R.B, PO, KN-R, KLu-R [21]

·        Vero E6 cells [11, 12, 19]

·        Vero cells caco2, pk-15, cl14 and HPEK [7, 8]

·        human airway epithelial cells [9, 68]

·        Human embryonic kidney cell line 293T [63]

·        human embryonic kidney cells (HEK-293) [69]

·        HeLa, HOS, C8166, BL41, Hep-2, Huh-7 and NIH3T3 cells [70]

·        LoVo Cells [19]

·        RAW264.7 cells [13,14]

·        human adenocarcinoma cells (A549) and Madin-Darby canine kidney (MDCK)cells [16, 17]

·        human lung epithelial (Calu-3) cells [18]

·        mouse pancreatic cell line and Mouse Insulinoma cell line (MIN6) [22]

2D Cell Culture

·        blood vessel and kidney organoids [38]

·        bronchial organoid [39]

·        liver organoid [41]

·        lung organoid [43]

·        small intestinal organoids [40]

·        colonic organoid [42]

·        organoid-derived human airway cells [44]

·        alveolar organoid [45]

·        brain organoid [47]

·        eye organoid [48]

·        intestinal organoid [36]

-

·        human airway organoid [28]

·        intestinal organoid [71]

Organoid

3D Cell Culture

·        alveolus chip [54]

·        intestine-on-chip [55]

·        human blood–brain barrier [72]

-

-

·        human airway Chip microfluidic culture device [52]

·        airway model within the PREDICT96-ALI platform [53]

Microfluidic device

-

-

-

·        3D lung models with A549 cells [66]

3D bioprinting