Table 1: Cell culture models to study
viruses (SARS‐CoV, H1N1, MERS‐CoV, SARS‐CoV‐2).
MERS-CoV |
SARS-CoV |
Influenza A (H1N1) |
|||
·
Vero cells [32] ·
Vero E6 cells [23,
24, 26, 27, 32] ·
Human airway
epithelial cells [29] ·
human
adenocarcinoma cells (A549), human liver cells (HUH7.0), and human embryonic
kidney cells (HEK-293T) [25] ·
human lung
epithelial (Calu-3) cells [15] ·
primary human
alveolar epithelial cells and macrophages [28] ·
Caco2, CL14,
HT-29, and DLD-1 [31] |
·
Huh7 cells [10] ·
human airway
epithelial cells [66, 68] ·
Monocyte-derived-dendritic
cells (Mo-DCs) [20] ·
human
adenocarcinoma cells (A549), ZN-R, ZLu-R, LGK-1-R, TT-R.B, PO, KN-R, KLu-R [21] |
·
Vero E6 cells [11, 12, 19] ·
Vero cells
caco2, pk-15, cl14 and HPEK [7, 8] ·
human airway
epithelial cells [9, 68] ·
Human embryonic
kidney cell line 293T [63] ·
human embryonic
kidney cells (HEK-293) [69] ·
HeLa, HOS,
C8166, BL41, Hep-2, Huh-7 and NIH3T3 cells [70] ·
LoVo Cells [19] |
·
RAW264.7 cells [13,14] ·
human adenocarcinoma
cells (A549) and Madin-Darby canine kidney (MDCK)cells [16, 17] ·
human lung
epithelial (Calu-3) cells [18] ·
mouse
pancreatic cell line and Mouse Insulinoma cell line
(MIN6) [22] |
2D Cell
Culture |
|
·
blood vessel
and kidney organoids [38] ·
bronchial
organoid [39] ·
liver organoid [41] ·
lung organoid [43] ·
small
intestinal organoids [40] ·
colonic
organoid [42] ·
organoid-derived
human airway cells [44] ·
alveolar
organoid [45] ·
brain organoid [47] ·
eye organoid [48] |
·
intestinal
organoid [36] |
- |
·
human airway
organoid [28] ·
intestinal
organoid [71] |
Organoid |
3D Cell
Culture |
·
alveolus chip [54] ·
intestine-on-chip
[55] ·
human
blood–brain barrier [72] |
- |
- |
·
human airway
Chip microfluidic culture device [52] ·
airway model
within the PREDICT96-ALI platform [53] |
Microfluidic
device |
|
- |
- |
- |
·
3D lung models
with A549 cells [66] |
3D
bioprinting |