Disease-free survival

Overall survival

HR

95％CI

P

HR

95％CI

P

Univariate analysis

Gender

0.739

0.396-1.379

0.342

1.077

0.553-2.096

0.828

Age 40

NF1 type

1.209

5.691

0.649-2.253

2.052-15.787

0.550

0.001

0.829

3.636

0.413-1.663

1.354-9.762

0.598

0.010

Tumor site

1.577

1.013-2.454

0.044

0.888

0.561-1.405

0.612

Tumor size

1.121

0.760-1.652

0.564

0.937

0.609-1.442

0.767

AJCC stage

1.485

1.070-2.061

0.018

1.337

0.938-1.905

0.108

Radiotherapy

0.484

0.254-0.922

0.027

0.654

0.328-1.305

0.229

Chemotherapy

0.761

0.397-1.459

0.411

0.618

0.310-1.230

0.170

Surgical type

1.175

0.619-2.231

0.622

1.216

0.593-2.491

0.594

Recurrence

19.185

5.657-65.057

0.000

3.035

1.318-6.988

0.009

Metastasis

3.560

1.880-6.743

0.000

   2.749

1.415-5.342

0.003

TBX2

3.405

1.668-6.951

0.000

5.104

2.193-11.880

0.000

CHK2

2.007

1.078-3.737

0.025

3.250

1.649-6.405

0.001

p53

Ki67

CycilnD1

1.962

2.201

1.012

1.011-3.808

1.184-4.090

0.516-1.988

0.042

0.010

0.971

2.050

1.700

1.431

1.016-4.137

0.882-3.279

0.645-3.175

0.041

0.109

0.376

Multivariate analysis

NF1 type

Tumor site

AJCC stage

Radiotherapy

Recurrence

Metastasis

TBX2

CHK2

p53

Ki67

1.862

1.011

0.758

0.938

8.051

0.502

2.920

0.776

0.255

1.533

0.606-5.722

0.557-1.835

0.492-1.167

0.423-2.078

3.013-49.204

0.187-1.343

0.952-8.960

0.362-1.667

0.088-0.738

0.615-3.922

0.278

0.972

0.208

0.874

0.000

0.170

0.061

0.516

0.012

0.352

1.631

-

-

-

0.646

0.576

3.491

2.639

1.710

-

0.582-4.573

-

-

-

0.255-1.635

0.240-1.381

1.181-10.315

1.239-5.624

0.776-3.770

-

0.352

-

-

-

0.357

0.216

0.024

0.012

0.183

-