[9]

Fumarylacetoacetase

Fah

0.94

2.2

Live cancer;

hepatic necrosis;

implanted secondary tumor

Nu

fumarylacetoacetase

activity

L-phenylalanine,tyrosine,phenylalanine,

arginine catabolic process;

metal ion binding;

hydrolase

Metabolism of

amino acids

[10]

Ribonuclease UK114

Uk114

1.3

2.1

Cancer

Mito

endonuclease

activity

inhibition of the translation by cleaving mRNA;

endonuclease;

tyrosine catabolic process;

regulation of translational termination;

[11]

Betaine-homocysteine S-methyltransferase 1

Bhmt

0.99

2

Prostate

cancer

Cyto

homocysteine S-methyltransferase

activity

protein methylation;

regulationhomocysteinemetabolicprocess;

S-methyltransferase activity;

Amino-acid biosynthesis

Metabolism of

amino acids

[12]

Isoform 4 of General

vesicular transport

factor p115

Uso1

1.1

2

Liver cancer;

Prostate cancer

Cyto

protein transporter

activity

intracellular protein transport；

apoptosis；

actin and microtubules;

[13]

Sulfite oxidase

Suox

1.4

1.8

Prostate cancer

Mito

Sulfite-oxidaseactivity;

electron carrier activity

oxidation-reduction process;

response to nutrient

Metabolism of

sulfur

[14]

Aspartate

aminotransferase

Got1

1.4

1.8

Liver cancer

Mito

L-aspartate:2-oxoglutarate aminotransferaseactivity;

phosphatidylserine decarboxylase activity

amino acid metabolism;

the urea and tricarboxylic acid (TCA) cycles

Metabolism of

amino acids

[15]

Pterin-4a-carbinolamine dehydratase

Pcbd1

1.3

1.8

dysplasia;

early stages of

cancer;

malignant transformation;

Cyto

phenylalanine 4-monooxygenase

activity

L-phenylalanine catabolic process;

positive regulation

of transcription;

tetrahydrobiopterin biosynthetic process;

Metabolism of

amino acids

[16]

Annexin A2

Anxa2

1.2

1.7

Liver cancer；

Cyto

calcium-dependent phospholipid binding

cytoskeletal protein binding;

Rab-GTPasebinding;

phosphatidylinositol-4,5-bisphosphate binding

Prostaglandin Synthesis and

Regulation

[17]

4-aminobutyrate aminotransferase

Abat

1.2

1.7

Liver cancer

Mito

4-aminobutyrate

transaminase activity

transaminase activity;

gamma-aminobutyric acid catabolic;

DNA-damaging product formation;

Metabolism of

amino acids

[18]

4-hydroxy-2-oxoglutarate aldolase

Hoga1

1.2

1.6

engineered invasive esophageal squamous cell

carcinoma

Mito

catalytic activity

metabolic pathway of hydroxyproline

Metabolism of

hydroxyproline

[19]

Serine hydroxymethyl

transferase 2

Shmt2

1.3

1.6

Prostate cancer

Mito

transferase activity

Regulation of metabolism;

Serine+tetrahydrofolate=glycine+5,10-methylene tetrahydrofolate

Metabolism of

cyanoamino acid

[20]

Microtubule-associated protein RP/EB family

member 1

Mapre1

1.2

1.5

Gastric cancer

Cyto

microtubule plus-end

binding

Cytoskeleton;

mitosis;

microtubule organizing center

Cell Cycle

G2/M Transition

[21]

Coiled-coil-helix-coiled

-coil-helix

domain-containing protein 3

Chchd3

1.4

1.5

Anaplastic

Cancer

Mito

phosphatase binding

mitochondrial fusion

[22]

Destrin

Dstn

1.4

1.5

Prostate cancer

Cyto

actin binding

actin cytoskeleton;

positive regulation of

actin filament depolymerization;

actin filament severing;

[23]

Isoform 1 of

Phosphotriesterase-related protein

Pter

0.95

1.5

Colon cancer;

Leukemia; Prostate cancer

Cyto

hydrolase activity;

zinc ion binding

catabolic process

[15]

Phosphoglycerate

kinase 1

Pgk1

0.97

0.67

Cyto

Phosphoglycerate

kinase activity

glycolysis;

ATP binding;

phosphoglycerate kinase activity;

transferase activity;

Gluconeogenesis

[24]

Legumain

Lgmn

0.93

0.66

Leukemia; colorectal

cancer

Cyto

peptidase activity

serine/threonine kinase activity;

cysteine-type endopeptidase;

negative regulation of growth

Lysosome

[25]

Isoform 1 of Core

histone macro-H2A.1

H2afy

0.99

0.64

Colon cancer;

leukemia

Nu

chromatin binding

nucleosome assembly;

chromatin modification

Systemic lupus

erythematosus

[26]

Succinatedehydrogenase

[ubiquinone]

iron-sulfur subunit,

Sdhb

0.98

0.61

Mito

protein binding

glycerol-3-phosphate

dehydrogenase complex;

glycerophosphate shuttle;

oxidoreductase

TCA Cycle

[27]

Isoform 1 of

Eukaryotic translation

initiation factor 4 gamma 1

Eif4g1

0.84

0.59

Sorcoma;

Leukemia; mitochondrial disorder;

Hepatitis; Colorectal

cancer

Cyto

translation initiation

factor activity

regulation of translation

Metabolism of mRNA; translation;

PI3K Cascade;

eIF4F complex;

mTOR signalling

pathways

[28]

Histidinetriad

nucleotide-binding

protein 2

Hint2

0.77

0.59

Prostate cance;

Colon caner;

leukemia

Mito

catalytic activity

Apoptosis;

steroid biosynthetic;

hydrolase

[29]

Cytochrome P450 2F2

Cyp2f2

0.87

0.58

Growth supperssion; insulin resistant;

ER

Monooxygenase;

electron carrier;

oxidoreductase activity

response to toxin;

naphthalene metabolic process

Metabolism of

xenobiotics by

cytochrome P450

[30]

Cathepsin B

Ctsb

0.98

0.58

mitochondrial disorder; hepatitis; leukemia;

prostate cancer

Mito

Cyto

cysteine-type

endopeptidase activity

response to wounding;

endopeptidase;

response to stress;

negative regulation of apoptosis

Lysosome

[31]

Isoform 1 of Lon

protease homolog 2

Lonp2

0.95

0.54

Liver cancer;

leukemia

Pero

protein binding

signal peptide processing;

ATPase;

serine-type endopeptidase

Metabolism of

proteins

[32]

ATP synthase subunit f

Atp5j2

1

0.51

hepatitis; leukemia; carcinoma in

situ lesion

Mito

ATPase activity

transmembrane transporter;

ATPase;

mitochondrial proton-transporting

ATP synthase complex

Oxidative phosphorylation; Electron Transport Chain

[33]

Majoy urinary protein 20

Mup20

0.62

0.37

pheromone binding

olfactory learning

[34]

Isoform 1 of

Adenylosuccinate

synthetase isozyme 1

Adssl1

0.89

0.63

Liver cancer;

colorectal cancer; obesity;

leukemia

Cyto

adenylosuccinate

synthase activity

purine nucleotide biosynthetic;

adenylosuccinate synthase;

AMP biosynthetic

Metabolism of

amino acids

[35]

Cytochrome

P450 3A13

Cyp3a13

0.67

0.57

insulin resistant;

liver cancer

ER

Monooxygenase;

electron carrier;

aromatase;

iron ion binding

Metabolism of xenobiotics by

cytochrome P451

Monooxygenase; electron carrier;

aromatase;

iron ion binding

[36]

Long-chain specific

acyl-CoA dehydrogenase

Acadl

1.6

1.5

sarcoma

Mito

Cyto

lipid catabolic;

negative regulation of fatty acid oxidation;

long-chain-acyl-CoA dehydrogenase

TCA Cycle