Table 2: Comparisons of concentrations of biochemical parameters in patients with an early (regression of development before age of 5-8 months) versus late onset (regression of development at age of 10-24 months) of RTT. Data are mean (SD).
|
Parameter |
Early onset n=6 |
Late onset n=9 |
P-value |
|
CSF-ACTH ng/ml |
34.5 (7.4) |
29.8 (6.5) |
0.41 |
|
CSF-glutamate nmol/l |
315 (100) |
389 (113) |
0.25 |
|
CSF-IGF-1 µg/l |
0.46 (0.18) |
0.49 (0.22) |
1.0 |
|
CSF-ACTH/glutamate-ratio |
0.11 (0.03) |
0.07 (0.01) |
0.032 |
|
CSF-IGF-1/glutamate-ratio |
0.0014 (0.0005) |
0.0014 (0.0009) |
0.84 |
|
CSF-Acetylcholinesterase activity nmol/mg prot/minute |
70.3 (19.9) |
81.6 (34.5) |
0.79 |
|
CSF-Nerve growth factor pg/ml |
2.27 (3.75) |
1.87 (2.48) |
0.53 |
CSF=cerebrospinal fluid, ACTH=adrenocorticotropic hormone, IGF= insulin-like growth factor.