Spontaneous Regression of a Poorly Differentiated Hepatocellular Carcinoma: A Case Report

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Author Info

Takahiko Omameuda Miyato H Sakuma Y Sata N Kawarai Lefor A

Corresponding Author

Takahiko Omameuda
Department of Surgery, Division of Gastroenterological, General and Transplant Surgery, Jichi Medical University, Shimotsuke, Tochigi, Japan

A B S T R A C T

Hepatocellular carcinoma (HCC) is the most common histological type of primary liver cancer, and spontaneous regression of HCC is rare. We report the case of a 76-year-old male diagnosed with poorly differentiated HCC that spontaneously regressed. Although the patient did not undergo any treatment or invasive diagnostic tests, such as angiography, before surgery, the resected tumor showed complete necrosis similar to that seen after transcatheter arterial embolization. The main cause of the necrosis in the present case was thought to be the occlusion of nutrient vessels and tumor hypoxia. Tumor hypoxia and immunological reactions are reported to be the main causes of spontaneous HCC regression, although the underlying mechanisms remain unclear. In this case report, we provide additional insights into this phenomenon.

Article Info

Article Type

Case Report

Publication history

Received: Mon 31, Jul 2023
Accepted: Mon 28, Aug 2023
Published: Fri 08, Sep 2023

Copyright

© 2023 Takahiko Omameuda. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Hosting by Science Repository.
DOI: 10.31487/j.AJSCR.2023.03.01