Clinical Significance of Antibiotic Prophylaxis in Children Diagnosed with LowGrade (I-III) Vesicoureteral Reflux

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Author Info

Yalda Ravanshad Mohadese Golsorkhi Anoush Azarfar Azam Ghezi Sahar Ravanshad Gholamreza Sarvari Sepideh Seyedkaboli

Corresponding Author

Anoush Azarfar
Kidney Transplantation Complications Research Center, Mashhad University of Medical Sciences, Mashhad, Iran

A B S T R A C T

Objective: The benefit of continuing and low-dose antibiotic therapy in urinary tract infection (UTI) prevention and renal injury for children diagnosed with primary vesicoureteral reflux (VUR) is not obvious. Materials and Methods: Patients aged between 2 to 71 months with VUR grade I–III with UTI proved microbiologically were randomly classified into two groups to receive either antibiotic prophylaxis (50 mg/kg cephalexin) daily or nothing at all for one year. The main outcome was symptomatic UTI confirmed by lab tests. Results: A total of 60 children diagnosed with VUR grade I through III were enrolled in this study; At least five (17%) symptomatic UTI reported in 29 patients receiving antibiotic prophylaxis and four (12%) in 31 patients receiving no antibiotics at all. Results revealed that continuing and low-dose antibiotic prophylaxis does not significantly reduce the risk of symptomatic UTI in children with mild to moderate VUR. Conclusion: The use of antibiotic prophylaxis in preventing recurrent infections and kidney scar formation in children with VUR grade I-III is not supported by this study.

Article Info

Article Type

Research Article

Publication history

Received: Mon 11, May 2020
Accepted: Sat 06, Jun 2020
Published: Fri 12, Jun 2020

Copyright

© 2023 Anoush Azarfar. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Hosting by Science Repository.
DOI: 10.31487/j.CEI.2020.02.02