Synthesis, Characterization and Cytotoxic Studies of Benzamide Derivatives of Anacardic Acid using Human Liver Cancer Cells

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Author Info

Basappa . Dinesh Rangappa K.N. Thanuja Kanchugarakoppal S. Rangappa M. Navya Rani Toreshetahally R. Swaroop

Corresponding Author

Dinesh Rangappa
Department of Nanotechnology, Visvesvaraya Technological University, Center for Postgraduate Studies, Bengaluru, India

A B S T R A C T

Naturally occurring anacardic acid based benzamides were reported to show anti-inflammatory and anticancer activities, where we synthesized and characterized by NMR and HRMS analysis and also tested a series of anacardic acid based benzamides and evaluated against the proliferation of human liver cancer cells (HepG2). Among the tested compounds, 6j-m showed good inhibitory activity against HepG2 cells with IC50 values ranging from 78.2-91.9 μM. In conclusion, we herein reported the newer series of an academic acid benzamides for the first time.

Article Info

Article Type

Research Article

Publication history

Received: Tue 07, Apr 2020
Accepted: Mon 20, Apr 2020
Published: Mon 27, Apr 2020

Copyright

© 2023 Dinesh Rangappa. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Hosting by Science Repository.
DOI: 10.31487/j.COR.2020.04.07