Malignant Ovarian Dysgerminoma Following Ovulation Induction in Patients with Polycystic Ovarian Syndrome: A Literature Review and Two Case Reports

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Author Info

Ahmed Said Khaled Zalata Naser El-lakkany Reda Hemida

Corresponding Author

Reda Hemida
Department of Obstetrics and Gynecology, Mansoura University, Egypt

A B S T R A C T

Background: The relation of ovarian induction drugs to development of ovarian cancer is still unclear. Polycystic ovary syndrome (PCOS) is a complex endocrine disorder that has been reported as a risk factor for ovarian cancer in some studies. Case presentation: We report two cases with polycystic ovarian syndrome who developed a malignant ovarian dysgerminoma following use of ovulation induction drugs. One of them was diagnosed during fifth month of pregnancy by intracytoplasmic injection (ICSI). Both cases were treated with conservative surgery. Conclusion: We reported 2 cases of ovarian dysgerminoma in patients with PCOS following ovarian stimulation. A large multicenter observational study is recommended to investigate a possible association.

Article Info

Article Type

Case Report and Review of the Literature

Publication history

Received: Fri 08, May 2020
Accepted: Thu 21, May 2020
Published: Thu 28, May 2020

Copyright

© 2023 Reda Hemida. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Hosting by Science Repository.
DOI: 10.31487/j.COR.2020.05.12