Primary Cutaneous Diffuse Large B-Cell Lymphoma, Leg Type: A Narrative Review

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Author Info

Nathaniel A. Parker Ammar Al-Obaidi Al Hadeethi D Choucair K Truong PV

Corresponding Author

Nathaniel A. Parker
Department of Internal Medicine, University of Kansas School of Medicine, Wichita, Kansas, USA

A B S T R A C T

Primary cutaneous lymphomas are rare manifestations of extranodal lymphomas. Comprising the majority of cutaneous lymphoma cases with neoplastic B-cell origins, three main subtypes exist. In general, grossly and microscopically these subtypes are similar. However, these are three distinct variants with diverse clinicopathologic, cytogenetic, molecular, and prognostic features. Primary cutaneous diffuse large B-cell lymphoma, leg type is an exceedingly rare and aggressive variant of primary cutaneous B-cell lymphomas. Thus, increased clinical awareness is needed to differentiate between the three subtypes because earlier identification not only leads to the appropriate treatment, but also improved survival. Here, characteristic features of the three predominant variants of primary cutaneous B-cell lymphomas are presented while remaining focused on the most aggressive subtype- primary cutaneous diffuse large B-cell lymphoma, leg type.

Article Info

Article Type

Review Article

Publication history

Received: Mon 15, Jun 2020
Accepted: Thu 09, Jul 2020
Published: Mon 20, Jul 2020

Copyright

© 2023 Nathaniel A. Parker. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Hosting by Science Repository.
DOI: 10.31487/j.COR.2020.07.07