Bovine Leukemia Virus Non-Productive Infection of Human Mammary Epithelial Cells (MCF10A)

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Author Info

Lucía Martínez Cuesta Pamela A Lendez Maureen A Sheahan Raymond RR Rowland Maria Victoria Nieto Farias Guillermina L Dolcini Maria Carolina Ceriani

Corresponding Author

Maria Carolina Ceriani
Laboratorio de Virología, Centro de Investigación Veterinaria de Tandil (CIVETAN, CONICET-CICPBA), Facultad de Cs. Veterinarias, UNCPBA, Buenos Aires, Argentina

A B S T R A C T

Bovine leukemia virus (BLV) is a retrovirus that causes lymphosarcoma in cattle. Some researchers suggest that BLV could be related to breast cancer development, however, evidence that the virus can infect the human counterpart is lacking. For that reason, the objective of this study was to infect in vitro a human mammary epithelial cell line (MCF10A) with BLV. The results suggest that the infection is non-productive, since only a fragment of the viral gene pol was detected in the cellular DNA. These results are consistent with previous studies, where fragments of different BLV genes were found in human mammary tissue. Future studies should investigate whether this non-productive infection can be associated with human breast cancer.

Article Info

Article Type

Research Article

Publication history

Received: Fri 14, Aug 2020
Accepted: Fri 28, Aug 2020
Published: Wed 30, Sep 2020

Copyright

© 2023 Maria Carolina Ceriani. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Hosting by Science Repository.
DOI: 10.31487/j.COR.2020.09.03