Metastasizing Ameloblastoma: A Systematic Review in Search of Clinicopathological Predictors

Download Citation in txt Download Citation in bib Download Citation in ris

Author Info

Juan Fernando Buestan Zambrano Maria de Lourdes Rodriguez Coyago

Corresponding Author

Juan Fernando Buestan Zambrano
Graduate Student, School of Dentistry, University of Cuenca, Cuenca, Ecuador

A B S T R A C T

Introduction: Ameloblastoma is a benign odontogenic tumor that is aggressive and localised in nature, listed as the first or second most prevalent odontogenic tumor and rarely tends to metastasis, but when it does, it receives the definition adopted by the WHO in 2017 of metastasizing ameloblastoma. Materials and Methods: This systematic review of clinical case reports of metastasizing ameloblastoma from the last 10 years, collected from PubMed, ScienceDirect and Cochrane digital databases, aims to search for association between clinical/pathological and/or molecular parameters of ameloblastoma and its metastatic potential. Results: The targeted search yielded 14 publications with a total of 18 clinical cases, which showed a mean age for diagnosis of metastasizing ameloblastoma of 46 years, with no gender predilection and a high probability of occurrence in the yellow Asian race, favouring a pattern of distant dissemination. The highest frequency of metastasis was associated with mandibular primary lesions diagnosed in young patients, and the most frequently found variant was the multicystic solid type, follicular subtype; distant metastasis was the predominant form of presentation, with the lungs being the main target. Conclusion: At the moment, there is nothing that can predict metastatic potential in ameloblastoma. More standardised studies exploring the molecular terrain are needed, as this is a key and understudied factor.

Article Info

Article Type

Review of Literature

Publication history

Received: Tue 01, Jun 2021
Accepted: Sat 12, Jun 2021
Published: Thu 01, Jul 2021

Copyright

© 2023 Juan Fernando Buestan Zambrano. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Hosting by Science Repository.
DOI: 10.31487/j.DOBCR.2021.03.01