Isoabsorptive Point Method for Simultaneous Determination of Paracetamol and Orphenadrine Citrate in Their Combined Pharmaceutical Dosage Forms

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Author Info

Amr A. Mattar Mahmoud Mohammed Mohammed Sebaay

Corresponding Author

Mahmoud Mohammed Mohammed Sebaay
Medicinal Chemistry Department, Faculty of Pharmacy, Zagazig University, Zagazig 44519, Egypt

A B S T R A C T

A simple, specific, accurate and precise spectrophotometric method was settled for simultaneous determination of paracetamol and orphenadrine citrate in their pure form and in their pharmaceutical formulation. Isoabsorptive point technique has been used in simultaneous determination of both drugs without prior separation. Isoabsorptive point method parameters were validated according to ICH guidelines in which accuracy, precision, repeatability and robustness were found in accepted limits. Advantages and disadvantages of Isoabsorptive point were discussed and statistical comparison between the proposed method and the reference one was also performed.

Article Info

Article Type

Research Article

Publication history

Received: Tue 03, Dec 2019
Accepted: Thu 02, Jan 2020
Published: Mon 13, Jan 2020

Copyright

© 2023 Mahmoud Mohammed Mohammed Sebaay. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Hosting by Science Repository.
DOI: 10.31487/j.GDT.2020.01.01