Electrospun Nanofibrous Poly(3-Hydroxybutyrate-Co-3-Hydroxyvalerate) With Antibacterial Activity

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Author Info

Samir Abbad Andaloussi Davy Louis Versace Estelle Renard Etienne Dessauw Valerie Langlois

Corresponding Author

Valerie Langlois
Institut de Chimie et des Matériaux de Paris-Est, UMR 7182, CNRS-UPEC, 2-8 rue Henri Dunant, 94320 Thiais, France

A B S T R A C T

Elaboration of electrospun nanofibrous poly(3-hydroxybutyrate-co-3-hydroxyvalerate) (PHBHV)-based mats was implemented through two routes to obtain antibacterial material containing carvacrol, a phenolic compound extracted from essential oils. The first strategy relied on a direct blend of PHBHV and carvacrol/-cyclodextrin inclusion complexes, PHBHV (carvCD-IC), while the second approach implied the elaboration of multilayered scaffold via the introduction of poly(β-CD-epichlorohydrin), PolyCD. The PolyCD/carv-based mat was electrospun between two hydrophobic PHBHV mats. Scanning Electron Microscopy analysis of mats showed uniform and beadless fibers. The three layered materials [PHBHV- (PolyCD/carv)-PHBHV] is sufficient to ensure optimal antiradical activity (RSA of 88.6%) and exhibit interesting antibacterial activities against E. coli and S. aureus.

Article Info

Article Type

Research Article

Publication history

Received: Wed 19, Jun 2019
Accepted: Fri 09, Aug 2019
Published: Sat 17, Aug 2019

Copyright

© 2023 Valerie Langlois. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Hosting by Science Repository.
DOI: 10.31487/j.JBEM.2019.01.02