Synthesis and Antimicrobial Activities of Containing Sulfur Heterocyclic Curcumin Derivatives

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Author Info

Dan Wang Dunjia Wang Heng Lyu Hengyi Du Lian Cai

Corresponding Author

Dunjia Wang
College of Chemistry and Chemical Engineering, Hubei Key Laboratory of Pollutant Analysis and Reuse Technology, Hubei Normal University, Huangshi, China

A B S T R A C T

Eight novel containing sulfur heterocyclic curcumins were synthesized and characterized by 1H-NMR, FTIR and MS spectroscopy. Their antimicrobial activities against Staphylococcus aureus, Bacillus subtilis, Escherichia coli and Aspergillus niger were also tested for MIC by using serial tube dilution method. The results showed that the antimicrobial activities of synthesized curcumin derivatives were better than curcumin. Especially, the compound 4-(1,3-dithiolan-2-ylidene)-1,7-di(thiophen-2-yl) hepta-1,6-diene-3,5- dione (2g) exhibited excellent the antimicrobial activities among these curcumin derivatives.

Article Info

Article Type

Research Article

Publication history

Received: Sat 04, Jan 2020
Accepted: Wed 22, Jan 2020
Published: Tue 28, Jan 2020

Copyright

© 2023 Dunjia Wang. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Hosting by Science Repository.
DOI: 10.31487/j.JBEM.2019.01.04