Interaction between Statins and Omega 3 Poly-unsaturated Fatty Acids in Cardiovascular Disease: Synergistic or Not?

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Author Info

Forel Céline Messager Laureen Sierra Camille Contreras Ivette Légère Simon Pessiot-Royer Solène Jean-Yves LE GUENNEC Demion Marie

Corresponding Author

Jean-Yves LE GUENNEC
Université de Montpellier, Inserm, CNRS, PhyMedExp, Montpellier, France

A B S T R A C T

Up to the middle of the 2000’s, omega 3 polyunsaturated fatty acids were considered has having cardioprotective properties. Patients having a myocardial infarction were supplemented with these fatty acids in secondary prevention of myocardial infarction. Since then, many randomized clinical trials failed to observe the cardioprotective effects previously described. The main hypothesis to explain such change is the systematic prescription of statins to patients following a myocardial infarction, statins interfering with the homeostasis of omega 3 fatty acids. This review discusses the effects of different forms of omega-3 in association with statins on cardiovascular disease and emphasize on the interaction between statins and omega 3 fatty acids leading to the possible need to use higher dose of fatty acids to get a synergistic effect.

Article Info

Article Type

Review Article

Publication history

Received: Wed 24, Jun 2020
Accepted: Mon 06, Jul 2020
Published: Fri 10, Jul 2020

Copyright

© 2023 Jean-Yves LE GUENNEC. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Hosting by Science Repository.
DOI: 10.31487/j.JICOA.2020.04.04