Prevalence and Outcome of Advanced Left Ventricular Diastolic Dysfunction among Consecutive Patients Referred for Echocardiography

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Author Info

Mady Moriel Adi Butnaru Marc Klutstein Rivka Farkash Michael Glikson David Rosenmann Shmuel Gottlieb

Corresponding Author

Mady Moriel
The Jesselson Integrated Heart Center, Shaare Zedek Medical Center, Jerusalem, Israel

A B S T R A C T

Aim: To assess the prevalence of advanced left ventricular diastolic dysfunction (LVDD) in a cohort of consecutive patients referred for echocardiography and its association with mortality. Methods: The cohort included 4,481 (85% hospitalized) patients who underwent echocardiography, had normal or preserved LV systolic function and diastolic function assessment. LVDD was graded as none or mild (0/I) and advanced grade (II/III). Mortality data were derived from the National Israeli Population Registry. Results: LVDD grade II/III was found in 1,262 patients (28%), was more prevalent among the elderly, females, diabetic and hypertensive patients. Independent predictors associated with LVDD grade II/III (OR; 95% CI) were: age (1-year increment) 1.015 (1.01-1.02), p<0.001; female sex 1.2 (1.04-1.39), p=0.012; hypertension 1.53 (1.30-1.80), p<0.001, while ischaemic heart disease was negatively associated 0.73 (0.63- 0.85), p<0.001. 1-year mortality rates were higher among grade II/III LVDD as compared to grade 0/I DD patients, 19% vs. 10.2%, respectively, p<0.0001. Independent predictors for all-cause mortality after adjusting for pertinent variables were: LVDD grade II/III 1.72 (1.40-2.11); age (1-year increment) 1.08 (1.07-1.09) and diabetes 1.54 (1.26-1.70), p<0.001 for all. Conclusion: LVDD grade II/III was more prevalent among the elderly, females, diabetic and hypertensive patients. Advanced LVDD was a strong independent predictor for all-cause mortality after adjustment for risk factors. Intensive pharmacological therapies at an earlier stage of LVDD may improve patients’ outcome.

Article Info

Article Type

Research Article

Publication history

Received: Fri 18, Dec 2020
Accepted: Sat 02, Jan 2021
Published: Thu 14, Jan 2021

Copyright

© 2023 Mady Moriel. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Hosting by Science Repository.
DOI: 10.31487/j.JICOA.2021.01.06