Microbiome in GIT Cancers: New Frontiers in Personalized Medicine – A Review of Literature

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Author Info

Maha Saad Mansour Mohamed Kabash Aymn El Sayed Shafei Rawan Ellackany Ahmed Atef Mostafa Wael Marwa Matboli

Corresponding Author

Maha Saad
Biochemistry Department, Faculty of Medicine, Modern University for Technology and Information, Cairo, Egypt

A B S T R A C T

Every person has a characteristic “enterotype,” the gut components and the environment. Recently, a strong biological correlation has emerged among the microbiome of the gut, the immune system, cancer development and pharmacological effects of chemotherapy. In this review, we outline the role of gut microbiota in the gastrointestinal tract (GIT) cancers pathogenesis and their implications for enhancing the efficacy of GIT cancer management in clinical practice. We also summarize the molecular pathways linking gut microbiota and GIT cancers and the effectiveness of manipulating microbiota in GIT cancer therapies such as personalized cancer therapy.

Article Info

Article Type

Review Article

Publication history

Received: Mon 12, Oct 2020
Accepted: Wed 25, Nov 2020
Published: Wed 16, Dec 2020

Copyright

© 2023 Maha Saad. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Hosting by Science Repository.
DOI: 10.31487/j.JSO.2020.05.03