High-intensity focused ultrasound as an effective and safe treatment for palliation of pain related to pancreatic cancer

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Author Info

Li LI Wei MAO Kun ZHAO Min YUAN Qing XU Yi YU Zhong zheng ZHU

Corresponding Author

Qing XU
Department of Oncology, Shanghai Tenth People's Hospital, Tongji University, Shanghai 200072, China

A B S T R A C T

This study was to evaluate the efficacy and safety of high intensity focused ultrasound (HIFU) in pain palliation of advanced unresectable pancreatic cancer. Twelve patients suffering cancer-related pain were treated with HIFU, and one case was treated a second time. The type and dose of analgesic drugs were obtained at baseline and during 12-week follow-up and converted to daily oral morphine dose. Post-HIFU pain relief, tumor ablation ratio, tumor reduction ratio in maximal tumor diameter, and adverse events were assessed. Pain was relieved in 11 cases (84.6%), with equal morphine dose reduction ratio from 23% to 100%. Complete pain relief was observed in 4 patients (30.8%), a partial pain relief was observed in 7 patients (53.8%), and no improvement of pain was observed in 2 patients (15.4%). Both tumor ablation ratio (P = 0.175) and tumor reduction in maximal diameter (P = 0.532) were not significantly associated with the reduction ratio of equal morphine dose. There were no severe adverse events related to HIFU therapy seen in any of the patients treated. Our data suggested that HIFU is an effective and safe treatment modality for palliation of the pain related to pancreatic cancer.

Article Info

Article Type

Research Article

Publication history

Received: Mon 17, Sep 2018
Accepted: Tue 25, Sep 2018
Published: Fri 05, Oct 2018

Copyright

© 2023 Qing XU. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Hosting by Science Repository.
DOI: 10.31487/j.RCO.2018.01.002