Primary and Secondary Angiosarcoma of the Breast: Report of Two Cases and Review of the Literature

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Author Info

Uriel Norberto Rivas-Mendoza Cristóbal Calixto-Martínez Raquel Valencia-Cedillo Jaime Resendiz-Colosia Jesús Alberto Sansón-Riofrio

Corresponding Author

Uriel Norberto Rivas-Mendoza
Surgical Oncology Resident, XXI Century National Medical Center, Mexico City, Mexico

A B S T R A C T

Introduction: The breast's angiosarcoma is a rare entity, representing 1% of the breast's malignant neoplasms and is classified as primary and secondary; the latter is associated with radiotherapy and chronic lymphedema. Clinically both present as a voluminous and rapidly growing lesion. Surgery is the cornerstone of a treatment since it provides the most outstanding local control, whereas radiotherapy and chemotherapy have little impact on the disease. Similarly, the oncological prognosis is poor because this type of tumor has a high recurrence rate and overall, 5-year survival of only 20%. Objective: Two cases of angiosarcoma of the breast (primary and secondary) are reported, both treated in the Breast Tumor Service and a bibliographic review of the disease is presented. Materials and Methods: All breast cancer cases were reviewed in the Breast Tumor Service for two years. Results: In the first clinical case, a 61-year-old patient was presented with a 5-month-old primary angiosarcoma in the right breast, treated with modified radical mastectomy. While in the second case, the clinical history of a 76-year-old woman with secondary breast angiosarcoma is related; the patient had a history of right breast cancer, treated ten years previously with conservative surgery, sentinel node and adjuvant radiotherapy. However, the woman presented local recurrence six years later, and she was operated on with a total mastectomy. Three years later, she developed an angiosarcoma in the surgical bed that warranted a wide resection of the chest wall. Conclusion: The breast's angiosarcoma is an aggressive and rare tumor of unknown aetiology, since it has a high recurrence rate and poor survival. Its main prognostic factors are tumor volume and resection margins. Therefore, early diagnosis is essential because it allows complete resection of the lesion.

Article Info

Article Type

Case Reports and Review of the Literature

Publication history

Received: Mon 15, Mar 2021
Accepted: Tue 30, Mar 2021
Published: Wed 14, Apr 2021

Copyright

© 2023 Uriel Norberto Rivas-Mendoza. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Hosting by Science Repository.
DOI: 10.31487/j.RCO.2021.01.02