A novel theranostics nanoparticles pGGA-PTX / SPION with bifunction of diagnosis and treatment

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Author Info

Hui Peng Jianzhong ZHU Jing Wang Lei Yu Lin Han Mingxue Fan Yiting Wang Zhiqiang Yan

Corresponding Author

Yiting Wang
Institute of Biomedical Engineering and Technology, Shanghai Engineering Research Center of Molecular Therapeutics and New Drug Development, School of Chemistry and Molecular Engineering, East China Normal University

A B S T R A C T

To increase the solubility of free drugs, drug-loaded efficiency and prolong the half-life of drugs in the body, a novel theranostics nano-particles, pGGA-PTX / SPION with a good diagnosis and treatment function have been fabricated. It is plump and uniform in size, to 113.0 ± 0.6nm, leading to the passive targeting of tumor tissue due to the EPR effect. The content-loaded of PTX was about 27.66%. The contrast agent content was about 6.34%. In vitro evaluation such as cell viability, the pGGA-PTX / SPION NPs were similar to that of PTX, suggesting a useful anticancer effect on tumor cells. In the H&E experiment, the pGGA-PTX / SPION did not impair the normal tissue and fully proved its safety performance. In vivo imaging, the pGGA-PTX / SPION in the tumor body can clearly be observed by NMR, to achieve real-time monitoring of drugs. In vivo treatment effects experiment, the pGGA-PTX / SPION exhibits a significant tumor growth inhibition effect.

Article Info

Article Type

Research Article

Publication history

Received: Wed 10, Oct 2018
Accepted: Fri 02, Nov 2018
Published: Mon 05, Nov 2018

Copyright

© 2023 Yiting Wang. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Hosting by Science Repository.
DOI: 10.31487/j.RDI.2018.10.06