Lynch Syndrome and Breast Cancer: Case Reports and Literature Review

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Author Info

Spyridon Marinopoulos Eleni Papamattheou Sofia-Dionysia Touriki Aris Giannos Constantine Dimitrakakis

Corresponding Author

Spyridon Marinopoulos
Breast Unit, 1st Department of Obstetrics and Gynecology, National and Kapodistrian University of Athens, “Alexandra” Hospital, Greece

A B S T R A C T

In the era of advanced cancer genomics, our knowledge of hereditary cancer mutations continues to expand. Lynch syndrome is one of the hereditary cancer predisposition syndromes associated with an increased lifelong risk of several types of cancer development, such as colorectal, endometrial, ovarian and other. This unique syndrome is an autosomal dominant inherited disease caused by mutations on EPCAM gene or on mismatch repair genes, which lead to microsatellite instability. In this article we will present three such cases visiting our clinic. They had breast cancer and a familial or personal history of malignancy. This article summarizes what we consider important about Lynch syndrome and breast cancer.

Article Info

Article Type

Case Reports and Review of the Literature

Publication history

Received: Thu 27, Aug 2020
Accepted: Fri 11, Sep 2020
Published: Wed 23, Sep 2020

Copyright

© 2023 Spyridon Marinopoulos. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Hosting by Science Repository.
DOI: 10.31487/j.SCR.2020.09.15