article = {CEI-2020-1-103} title = {Two-Way Relationship Between Helicobacter Pylori Infection and Periodontitis: Results from A Systematic Review and Meta-Analysis} journal = {Clinical and Experimental Investigations} year = {2020} issn = {2674-5054} doi = {http://dx.doi.org/10.31487/j.CEI.2020.01.03} url = {https://www.sciencerepository.org/two-way-relationship-between-helicobacter-pylori-infection_CEI-2020-1-103 author = { Silvania Conceição Furtado ,Alessandro Luiz Araújo Bentes Leal ,Any Carolina Cardoso Guimarães Vasconcelos ,Daniel Fernando Pereira Vasconcelos ,Felipe Rodolfo,José Fernando Marques Barcellos ,Juliana Gomes Galeno ,Larissa dos Santos Pessoa ,Reyce dos Santos Koga,Zinalton Gomes de Andrade ,} keywords = {Periodontal disease, gastrointestinal tract, odds ratio, periodontal medicine, risk factor} abstract ={Aim: Helicobacter pylori (H. pylori) infection and periodontitis have considerable worldwide prevalence once they both present systemic alterations with a possible association between them. Therefore, we have performed this meta-analysis to assess the possible association between H. pylori infection and periodontitis. Material and Methods: A systematic search in the literature was performed for studies published before December 2, 2019 in diverse scientific and educational databases. The data was extracted by two investigators and the statistical analysis was performed by Review Manager statistical program with heterogeneity and Odds Ratio (OR) with 95% of Confidence Intervals (CI) calculations as well as a sensitive analysis to assess the accuracy of the results. The value of P<0.05 was considered as significant. In addition, we performed the analysis of the quality of included studies as well as the evaluation for risk of bias. Results: In overall analysis, H. pylori infection was associated with the risk of periodontitis development (OR = 1.72, CI: 1.47, 2.02, P<0.00001) and the periodontitis was considered as a risk factor for H. pylori infection (OR = 3.21, CI: 2.31, 4.47, P<0.00001). Moreover, the evaluation of dental plaque from patients with periodontitis reveled increased risk of H. pylori infection (OR = 3.46, CI: 2.39, 5.01, P<0.00001). Conclusions: This current systematic review and meta-analysis composed by 12 studies in 7,059 participants showed that H. pylori infection increased significantly the risk of the development of periodontitis and the periodontitis may be a risk for this bacterial infection. }