article = {CEI-2020-2-103}
title = {Ten Year Retrospective Review of Bartter Syndrome at Sheikh Hospital 2008-2018}
journal = {Clinical and Experimental Investigations}
year = {2020}
issn = {2674-5054}
doi = {http://dx.doi.org/10.31487/j.CEI.2020.02.03}
url = {https://www.sciencerepository.org/ten-year-retrospective-review-of-bartter-syndrome-at-sheikh-hospital_CEI-2020-2-103 
author = {Yalda  Ravanshad,Mohadese  Golsorkhi,Anoush Azarfar,Sahar  Ravanshad,Zeinab  seyedin,Sepideh  Bagheri,Sepideh  Seyedkaboli,}
keywords = {Bartter syndrome, nephrocalcinosis, polyhydramnios, serum electrolytes}
abstract ={Objective: Bartter syndrome is a type of autosomal-recessive genetic abnormality with a low prevalence.
In this abnormality, due to the mutations in the cotransporters and channeling proteins that are responsible
for the transfer of sodium, chloride and potassium electrolytes in the thick ascending loop of Henle, the
body throws out a large amount of these electrolytes through the urine. Early birth (prematurity),
polyhydramnios, alkalosis and hypokalemia are the most important side effects of Bartter syndrome.
Accordingly, quick detection of this can improve the treatment.
Methods and Materials: The purpose of the current study is to investigate the symptoms of patients
referred to Sheikh Hospital (Mashhad, Iran) over the past ten years due to Bartter's syndrome. Accordingly,
by referring to patients' files, information about them is extracted from the historical documents and,
statistically analyzed. Patients are also requested to complete a questionnaire, if necessary, through a
telephone conversation.
Results: Our findings indicated that symptoms including fever, polyuria, polydipsia, nausea and seizure,
fever, physical and mental retardation, and one death among 14 participants were reported. Also, the
biochemical findings of this study showed that potassium ion (k+ ) concentration in the serum of neonates
was significantly lower than normal (p = 0.0001), and the concentration of calcium ions (Ca2+) and urea
composition was significantly higher than normal (p = 0.0001). Also, sonographic findings showed that
nephrocalcinosis and microlithiasis were observed in the participants in this study. Potassium chloride,
normal saline, Brufen and Aldactone were used for treatment.
Conclusion: It can be concluded that high concentrations of calcium and urea, low concentration of
potassium ion, and complications such as fever and seizure along with polyhydramnios and nephrocalcinosis
are the most important symptoms seen in patients with Bartter syndrome in the last 10 years.}