article = {CMR-2020-1-104}
title = {Evaluation of Anticancer Activities of Clerodendrum formicarum Gurke (Lamiaceae) and Syzygium Cordatum Hochst ex Krauss (Myrtaceae) Harvested in the City of Lubumbashi and its Surroundings in the Democratic Republic Of The Congo}
journal = {Clinical Microbiology and Research}
year = {2020}
issn = {2674-418X}
doi = {http://dx.doi.org/10.31487/j.CMR.2020.01.04}
url = {https://www.sciencerepository.org/evaluation-of-anticancer-activities-of-clerodendrum-formicarum-gurke-lamiaceae-and-syzygium_CMR-2020-1-104 
author = {Claude  Spino,Donald  Poirier,Emery Kalonda  Mutombo,Jenny  Roy,Kanyinda  Mulowayi,Kasongo  Kaseya,Marsi Mbayo  Kitambala,René  Gagnon,Topwe Milongwe Mwene-Mbeja,}
keywords = {Natural products, essential oils, breast cancer, chemical constituents}
abstract ={The main objective of this study was to extract the essential oils from Clerodendrum formicarum and
Syzygium cordatum in order to determine the anticancer activity and establish the chemical constituents of
that kind of essential oils. Hence, we have used hydrodistillation method to obtain the desired extracts or
samples of essential oils. Indeed, the assessment of the anticancer activities showed that, at 100 µg/mL, the
essential oils from S. cordatum inhibited the proliferation (98.2%) of breast cancer (MCF-7) cells. In the
same context, the essential oils from C. formicarum also inhibited the proliferation (98.9%) of breast cancer
(MCF-7) cells. We have additionally determined the chemical composition of the essential oils by GC-MS
and identified 17 compounds in C. formicarum including caryophyllene (18.6%), (E)-3,7-dimethylocta1,3,6-triene (7.6%), β-Myrcene (6.2%), and [1S-(1α, 7α, 8α)]-1,8a-dimethyl-7-(1-methylethenyl)-
1,2,3,5,6,7,8,8a-octahydronaphthalene (5.6%) as major compounds. We have observed an unknown
compound (25%) in the essential oils from C. formicarum (H-12) The chemical analysis showed 28
compounds in S. cordatum (HE-9) essential oils such as caryophyllene (7.2%) and cedrene (6.7%) as major
compounds}