article = {ORD-2019-1-102}
title = {Neutrophil Extracellular Traps: As Antimicrobial Peptides}
journal = {Oral Rehabilitation and Dentistry}
year = {2019}
issn = {2733-2543}
doi = {http://dx.doi.org/10.31487/j.ORD.2019.01.02}
url = {https://www.sciencerepository.org/neutrophil-extracellular-traps-as-antimicrobial-peptides_ORD-2019-1-102 
author = {Quratul Ann,}
keywords = {Antimicrobial peptides, innate immunity, neutrophil extracellular traps (NETs), NETosis, periodontal disease, toll like receptors}
abstract ={Neutrophils are an integral part of innate immune response system, abundantly present in blood circulation.
They are the primary responders to the injury or intruding pathogens in human body. Neutrophils engulf
infectious microorganisms by the process of phagocytosis, which usually initiates the production of reactive
oxygen species and adhere the neutrophilic antimicrobial granules with vacuoles containing pathogens.
Upon activation, neutrophils also render signals for stimulation and maturation of macrophages and
dendritic cells. They release neutrophil extracellular traps for the suppression of infection and inflammation
along with other antimicrobial molecules. The antimicrobials that are present in neutrophil extracellular
traps not only eradicate microbes but also moderately contribute to the pathogenesis of various diseases
such as destruction of tissue observed in periodontitis. Genetic shortcomings in neutrophils with respect to
their chemotaxis, migration and phagocytosis become evident as severe forms of periodontitis, thus
highlighting their role in innate immunity. Therefore, the present review is undertaken to highlight the
importance of production and release of neutrophil extracellular trap in the regulation of immune reaction
and its role in periodontal disease. A comprehensive database search was performed to gather all the relevant
data related to the action of neutrophil and neutrophil extracellular traps in various inflammatory diseases
with special emphasis on periodontitis.
}