article = {RGM-2020-2-101}
title = {Autologous Adipose-Derived Stem Cells, Platelet-Rich Plasma, and Fibrin Enhance Healing of Mandibular Bone Defects in Swine}
journal = {International Journal of Regenerative Medicine}
year = {2020}
issn = {2613-5914}
doi = {http://dx.doi.org/10.31487/j.RGM.2020.02.01}
url = {https://www.sciencerepository.org/autologous-adipose-derived-stem-cells-platelet-rich-plasma-and-fibrin_RGM-2020-2-101 
author = {Aaron J.  Maki,Anna C.  Ercolin,Jamey J.  Cooper,Kelly S.  Roballo,Marcello  Rubessa,Matthew B. Wheeler,Rathnaweera A.C.  Rabel,}
keywords = {ASC, bone regeneration, fibrin, platelet-rich plasma, mandible, porcine}
abstract ={The primary aim of this study was to assess the therapeutic effects of autologous platelet-rich plasma and
fibrin scaffolds combined with autologous adipose stem cells (ASCs) for critical-size defects in the pig
mandible. Fibrin scaffolds supplemented with calcium hydrogen phosphate and platelet-derived growth
factors were hypothesized to accelerate healing in porcine mandible bone compared to ASC-only injections
and untreated controls. Three treatments included the use of autologous ASCs from liposuction with the
addition of platelet-rich plasma, fibrin scaffolds, or as cell-only controls. All three treatments using ASCs
were determined to increase bone mineral density and bone volume fraction compared to untreated controls.
In general, the addition of both platelet-rich plasma and fibrin scaffolds to autologous ASCs from
liposuction improved bone healing of critical-size defects.}