TY - JOUR
AR - CMR-2020-1-104
TI - Evaluation of Anticancer Activities of Clerodendrum formicarum Gurke (Lamiaceae) and Syzygium Cordatum Hochst ex Krauss (Myrtaceae) Harvested in the City of Lubumbashi and its Surroundings in the Democratic Republic Of The Congo
AU - Claude , Spino
AU - Donald , Poirier
AU - Emery Kalonda , Mutombo
AU - Jenny , Roy
AU - Kanyinda , Mulowayi
AU - Kasongo , Kaseya
AU - Marsi Mbayo , Kitambala
AU - René , Gagnon
AU - Topwe Milongwe, Mwene-Mbeja
JO - Clinical Microbiology and Research
PY - 2020
DA - Mon 29, Jun 2020
SN - 2674-418X
DO - http://dx.doi.org/10.31487/j.CMR.2020.01.04
UR - https://www.sciencerepository.org/evaluation-of-anticancer-activities-of-clerodendrum-formicarum-gurke-lamiaceae-and-syzygium_CMR-2020-1-104 
KW - Natural products, essential oils, breast cancer, chemical constituents
AB - The main objective of this study was to extract the essential oils from Clerodendrum formicarum and
Syzygium cordatum in order to determine the anticancer activity and establish the chemical constituents of
that kind of essential oils. Hence, we have used hydrodistillation method to obtain the desired extracts or
samples of essential oils. Indeed, the assessment of the anticancer activities showed that, at 100 µg/mL, the
essential oils from S. cordatum inhibited the proliferation (98.2%) of breast cancer (MCF-7) cells. In the
same context, the essential oils from C. formicarum also inhibited the proliferation (98.9%) of breast cancer
(MCF-7) cells. We have additionally determined the chemical composition of the essential oils by GC-MS
and identified 17 compounds in C. formicarum including caryophyllene (18.6%), (E)-3,7-dimethylocta1,3,6-triene (7.6%), β-Myrcene (6.2%), and [1S-(1α, 7α, 8α)]-1,8a-dimethyl-7-(1-methylethenyl)-
1,2,3,5,6,7,8,8a-octahydronaphthalene (5.6%) as major compounds. We have observed an unknown
compound (25%) in the essential oils from C. formicarum (H-12) The chemical analysis showed 28
compounds in S. cordatum (HE-9) essential oils such as caryophyllene (7.2%) and cedrene (6.7%) as major
compounds