TY - JOUR
AR - COR-2020-4-107
TI - Synthesis, Characterization and Cytotoxic Studies of Benzamide Derivatives of Anacardic Acid using Human Liver Cancer Cells
AU - Basappa, .
AU - Dinesh , Rangappa
AU - K.N. , Thanuja
AU - Kanchugarakoppal S. , Rangappa
AU - M. Navya , Rani
AU - Toreshetahally R. , Swaroop
JO - Clinical Oncology and Research
PY - 2020
DA - Mon 27, Apr 2020
SN - 2613-4942
DO - http://dx.doi.org/10.31487/j.COR.2020.04.07
UR - https://www.sciencerepository.org/synthesis-characterization-and-cytotoxic-studies-of-benzamide-derivatives_COR-2020-4-107 
KW - Anacardic acid, cytotoxic, HepG2, benzamid
AB - Naturally occurring anacardic acid based benzamides were reported to show anti-inflammatory and
anticancer activities, where we synthesized and characterized by NMR and HRMS analysis and also tested
a series of anacardic acid based benzamides and evaluated against the proliferation of human liver cancer
cells (HepG2). Among the tested compounds, 6j-m showed good inhibitory activity against HepG2 cells
with IC50 values ranging from 78.2-91.9 μM. In conclusion, we herein reported the newer series of an
academic acid benzamides for the first time.