TY - JOUR
AR - COR-2020-9-103
TI - Bovine Leukemia Virus Non-Productive Infection of Human Mammary Epithelial Cells (MCF10A)
AU - Lucía Martínez , Cuesta
AU - Pamela , A Lendez
AU - Maureen , A Sheahan
AU - Raymond , RR Rowland
AU - Maria Victoria , Nieto Farias
AU - Guillermina , L Dolcini
AU - Maria Carolina , Ceriani
JO - Clinical Oncology and Research
PY - 2020
DA - Wed 30, Sep 2020
SN - 2613-4942
DO - http://dx.doi.org/10.31487/j.COR.2020.09.03
UR - https://www.sciencerepository.org/bovine-leukemia-virus-non-productive-infection-of-human-mammary_COR-2020-9-103 
KW -  Bovine leukemia virus, breast cancer, infections
AB - Bovine leukemia virus (BLV) is a retrovirus that causes lymphosarcoma in cattle. Some researchers suggest
that BLV could be related to breast cancer development, however, evidence that the virus can infect the
human counterpart is lacking. For that reason, the objective of this study was to infect in vitro a human
mammary epithelial cell line (MCF10A) with BLV. The results suggest that the infection is non-productive,
since only a fragment of the viral gene pol was detected in the cellular DNA. These results are consistent
with previous studies, where fragments of different BLV genes were found in human mammary tissue.
Future studies should investigate whether this non-productive infection can be associated with human breast cancer.