TY - JOUR
AR - DOBCR-2021-3-101
TI - Metastasizing Ameloblastoma: A Systematic Review in Search of  Clinicopathological Predictors
AU - Juan Fernando Buestan, Zambrano
AU - Maria de Lourdes Rodriguez, Coyago
JO - Dental Oral Biology and Craniofacial Research
PY - 2021
DA - Thu 01, Jul 2021
SN - 2613-4950
DO - http://dx.doi.org/10.31487/j.DOBCR.2021.03.01
UR - https://www.sciencerepository.org/metastasizing-ameloblastoma-a-systematic-review_DOBCR-2021-3-101 
KW - Ameloblastoma, metastasis, metastasizing
AB - Introduction: Ameloblastoma is a benign odontogenic tumor that is aggressive and localised in nature, 
listed as the first or second most prevalent odontogenic tumor and rarely tends to metastasis, but when it 
does, it receives the definition adopted by the WHO in 2017 of metastasizing ameloblastoma.
Materials and Methods: This systematic review of clinical case reports of metastasizing ameloblastoma 
from the last 10 years, collected from PubMed, ScienceDirect and Cochrane digital databases, aims to search 
for association between clinical/pathological and/or molecular parameters of ameloblastoma and its 
metastatic potential.
Results: The targeted search yielded 14 publications with a total of 18 clinical cases, which showed a mean 
age for diagnosis of metastasizing ameloblastoma of 46 years, with no gender predilection and a high 
probability of occurrence in the yellow Asian race, favouring a pattern of distant dissemination. The highest 
frequency of metastasis was associated with mandibular primary lesions diagnosed in young patients, and 
the most frequently found variant was the multicystic solid type, follicular subtype; distant metastasis was 
the predominant form of presentation, with the lungs being the main target.
Conclusion: At the moment, there is nothing that can predict metastatic potential in ameloblastoma. More 
standardised studies exploring the molecular terrain are needed, as this is a key and understudied factor.